Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Kyriazopoulou, Evdoxia; Poulakou, Garyphallia; Milionis, Haralampos; Metallidis, Symeon; Adamis, Georgios; Tsiakos, Konstantinos; Fragkou, Archontoula; Rapti, Aggeliki; Damoulari, Christina; Fantoni, Massimo; Kalomenidis, Ioannis; Chrysos, Georgios; Angheben, Andrea; Kainis, Ilias; Alexiou, Zoi; Castelli, Francesco; Saverio Serino, Francesco; Τσιλικά, Μαρία; Bakakos, Petros; Nicastri, Emanuele; Tzavara, Vassiliki; Kostis, Evangelos; Dagna, Lorenzo; Koufargyris, Panagiotis; Dimakou, Katerina; Savvanis, Spyridon; Tzatzagou, Glykeria; Chini, Maria; Cavalli, Giulio; Bassetti, Matteo; Katrini, Konstantina; Kotsis, Vasilios; Tsoukalas, George; Selmi, Carlo; A. Bliziotis, Ioannis; Samarkos, Michael; Doumas, Michael; Ira Ktena, Sofia; Masgala, Aikaterini; Papanikolaou, Ιlias; Kosmidou, Maria; Myrodia, Dimitra-Melia; Argyraki, Aikaterini; Simona Cardellino, Chiara; Koliakou, Katerina; Katsigianni, Eleni-Ioanna; Rapti, Vassiliki; Giannitsioti, Efthymia; Cingolani, Antonella; Micha, Styliani; Akinosoglou, Karolina; Liatsis-Douvitsas, Orestis; Symbardi, Styliani; Gatselis, Nikolaos; Mouktaroudi, Maria; Ippolito, Giuseppe; Florou, Eleni; Kotsaki, Antigone; G. Netea, Mihai; Eugen‐Olsen, Jesper; Kyprianou, Miltiades; Panagopoulos, Periklis; Ν. Dalekos, George; J. Giamarellos‐Bourboulis, Evangelos

doi:10.1038/s41591-021-01499-z

Public

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Published in Nature Medicine • Sep 3, 2021

Authors:

Evdoxia Kyriazopoulou

Garyphallia Poulakou

Haralampos Milionis

Abstract

Abstract Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative of increased risk of progression of coronavirus disease 2019 (COVID-19) to respiratory failure. The SAVE-MORE double-blind, randomized controlled trial evaluated the efficacy and safety of ...

Subject

Anakinra

Medicine

Internal medicine

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