NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.

Yujun, Hou,; Yong, Wei,; Sofie, Lautrup,; Beimeng, Yang,; Yue, Wang,; Stephanie, Cordonnier,; Mark P, Mattson,; Deborah L, Croteau,; Vilhelm A, Bohr,

doi:10.1073/pnas.2011226118

Public

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.

Published in Proceedings of the National Academy of Sciences of the United States of America • Sep 14, 2021

Authors:

Hou, Yujun

Wei, Yong

Lautrup, Sofie

Abstract

Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of AD, but their interplay is not clear. Nicotinamide adenine dinucleotide (NAD+) is an important metabolite in all h...

Subject

Alzheimer’s disease

DNA repair

NAD supplementation

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