PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy

Liu, Jinhua; Chen, Zichao; Li, Yaqun; Zhao, Wenjie; Wu, Jibiao; Zhang, Zhen

doi:10.3389/fphar.2021.731798

Public

PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy

Published in Frontiers in Pharmacology • Sep 1, 2021

Authors:

Jinhua Liu

Zichao Chen

Yaqun Li

Abstract

Programmed death protein 1 (PD1) is a common immunosuppressive member on the surface of T cells and plays an imperative part in downregulating the immune system and advancing self-tolerance. Its ligand programmed cell death ligand 1 (PDL1) is overexpressed on the surface of malignant tumor cells, wh...

Subject

Immunotherapy

Immune checkpoint

Blockade

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