Emotional behavior and brain anatomy of the <i>mdx52</i> mouse model of Duchenne muscular dystrophy

Saoudi, Amel; Zarrouki, Faouzi; Sebrié, Catherine; Izabelle, Charlotte; Goyenvalle, Aurélie; Vaillend, Cyrille

doi:10.1242/dmm.049028

Public

Emotional behavior and brain anatomy of the mdx52 mouse model of Duchenne muscular dystrophy

Published in Disease Models & Mechanisms • Sep 1, 2021

Authors:

Amel Saoudi

Faouzi Zarrouki

Catherine Sebrié

Abstract

The exon-52-deleted mdx52 mouse is a critical model of Duchenne muscular dystrophy (DMD), as it features a deletion in a hotspot region of the DMD gene, frequently mutated in patients. Deletion of exon 52 impedes expression of several brain dystrophins (Dp427, Dp260 and Dp140), thus providing a key ...

Subject

Duchenne muscular dystrophy

Amygdala

Neuroscience

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