Genetic and epigenetic basis of hepatoblastoma diversity

Nagae, Genta; Yamamoto, Shogo; Fujita, Masashi; Fujita, Takanori; Nonaka, Aya; Umeda, Takayoshi; Fukuda, Shiro; Tatsuno, Kenji; Maejima, Kazuhiro; Hayashi, Akimasa; Kurihara, Sho; Kojima, Masato; Hishiki, Tomoro; Watanabe, Kenichiro; Ida, Kohmei; Yano, Michihiro; Hiyama, Yoko; Tanaka, Yukichi; Inoue, Takeshi; Ueda, Hiroki; Nakagawa, Hidewaki; Aburatani, Hiroyuki; Hiyama, Eiso

doi:10.1038/s41467-021-25430-9

Public

Genetic and epigenetic basis of hepatoblastoma diversity

Published in Nature Communications • Sep 20, 2021

Authors:

Genta Nagae

Shogo Yamamoto

Masashi Fujita

Abstract

Hepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary predisposition and acquired molecular aberrations related to HB clinicopathological diversity are not well understood. Here, we perform an integrative genomic profiling of 163 pediatric liver tumors (154 HBs and n...

Subject

Biology

Hepatoblastoma

Epigenetics

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