Pro-inflammatory and proliferative microglia drive progression of glioblastoma.

H, Liu; Y, Sun; Q, Zhang; W, Jin; RE, Gordon; Y, Zhang; J, Wang; C, Sun; ZJ, Wang; X, Qi; J, Zhang; B, Huang; Q, Gui; H, Yuan; L, Chen; X, Ma; C, Fang; YQ, Liu; X, Yu; S, Feng

doi:10.1016/j.celrep.2021.109718

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Pro-inflammatory and proliferative microglia drive progression of glioblastoma.

Shared by NobleBlocks on Sep 1, 2021 • 12:00 AM UTC

Authors:

Liu H

Sun Y

Zhang Q

Abstract

Scant understanding of the glioblastoma microenvironment and molecular bases hampers development of efficient treatment strategies. Analyses of gene signatures of human gliomas demonstrate that the SETD2 mutation is correlated with poor prognosis of IDH1/2 wild-type (IDH-WT) adult glioblastoma patie...

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