Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression

Parkinson Study Group SURE-PD3 Investigators, The; Bluett, Brent; M. Togasaki, Daniel; Mihaila, Dragos; L. Evatt, Marian; Rezak, Michael; Jain, Samay; A. Schwarzschild, Michael; Ascherio, Alberto; Casaceli, Cindy; C. Curhan, Gary; C. Fitzgerald, Rebecca; Kamp, Cornelia; Lungu, Codrin; A. Macklin, Eric; Marek, Kenneth; Mozaffarian, Dariush; Oakes, David; Rudolph, Alice; Shoulson, Ira; Videnović, Aleksandar; Scott, B.L.; Gauger, Lisa; Aldred, Jason; Bixby, Melissa; Ciccarello, Jill; A. Gunzler, Steven; Henchcliffe, Claire; Brodsky, Matthew; Keith, Kellie; A. Hauser, Robert; G. Goetz, Christopher; S. LeDoux, Mark; K. Hinson, Vanessa; Kumar, Rajeev; J. Espay, Alberto; Jimenez‐Shahed, Joohi; Hunter, Christine; W. Christine, Chadwick; Daley, Aaron; A. Leehey, Maureen; Antonelle de Marcaida, Joy; H. Friedman, Joseph; Y. Hung, Albert; Bwala, Grace; Litvan, Irene; K. Simon, David; Simuni, Tanya; Poon, Cynthia; C. Schiess, Mya; L. Chou, Kelvin; Park, Ariane; Bhatti, Danish; Peterson, Carolyn; R. Criswell, Susan; S. Rosenthal, Liana; Durphy, Jennifer; A. Shill, Holly; H. Mehta, Shyamal; Ahmed, Anwar; Deik, Andres; Y. Fang, John; Stover, Natividad; Zhang, Lin; B. Dewey, Richard; Gerald, Ashley; T. Boyd, James; Houston, Emily; Suski, Valerie; Mosovsky, Sherri; Cloud, Leslie; Shah, Binit; Saint‐Hilaire, Marie; James, Raymond; Elizabeth Zauber, S.; G. Reich, Stephen; Shprecher, David; Pahwa, Rajesh; Langhammer, April; LaFaver, Kathrin; A. LeWitt, Peter; L. Kaminski, Patricia; L. Goudreau, John; Russell, Doozie; Houghton, David; LaRoche, Ashley; Thomas, Karen; McGraw, Martha; Mari, Zoltan; Serrano, Carmen; Blindauer, Karen; Rabin, Marcie; Kurlan, Roger; C. Morgan, John; J. Soileau, Michael; Ainslie, Melissa; Bódis-Wollner, Iván; B. Schneider, Ruth; Waters, Cheryl; Servi Ratel, Amber; A. Beck, Christopher; Bolger, Patrick; F. Callahan, Katherine; F. Crotty, Grace; Klements, David; Kostrzebski, Melissa; M. McMahon, Gearoid; Pothier, Lindsay; S. Waikar, Sushrut; E. Lang, Anthony; Mestre, Tiago

doi:10.1001/jama.2021.10207

Public

Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression

Published in JAMA • Sep 14, 2021

Authors:

The Parkinson Study Group SURE-PD3 Investigators

Brent Bluett

Daniel M. Togasaki

Abstract

Importance: Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, and clinical data. Objective: To determine whether s...

Subject

Medicine

Internal medicine

Population

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!