Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial

Ader, Florence; Ader, Florence; Bouscambert-Duchamp, Maude; Hites, Maya; Peiffer-Smadja, Nathan; Poissy, Julien; Belhadi, Drifa; Diallo, Alpha; Lê, Minh-Patrick; Peytavin, Gilles; Staub, Thérèse; Greil, Richard; Guedj, Jérémie; Paiva, Jose-Artur; Costagliola, Dominique; Yazdanpanah, Yazdan; Burdet, Charles; Mentré, France; Egle, Alexander; Greil, Richard; Joannidis, Michael; Lamprecht, Bernd; Altdorfer, Antoine; Belkhir, Leïla; Fraipont, Vincent; Hites, Maya; Verschelden, Gil; Aboab, Jérôme; Ader, Florence; Ader, Florence; Ait‐Oufella, Hafid; Andréjak, Claire; Andreu, Pascal; Argaud, Laurent; Bani‐Sadr, Firouzé; Bénézit, François; Blot, Mathieu; Botelho-Nevers, Élisabeth; Bouadma, Lila; Bouchaud, Olivier; Bougon, David; Bouiller, Kévin; Bounes-Vardon, Fanny; Boutoille, David; Boyer, Alexandre; Bruel, Cédric; Cabie, André; Canet, Emmanuel; Cazanave, Charles; Chabartier, Cyrille; Chirouze, Catherine; Clère-Jehl, Raphaël; Courjon, Johan; Crockett, Flora; Danion, François; Delbove, Agathe; Dellamonica, Jean; Djossou, Félix; Dubost, C; Duvignaud, Alexandre; Épaulard, Olivier; Epelboin, Loïc; Fartoukh, Murielle; Faure, Karine; Faure, Emmanuel; Ferry, Tristan; Ficko, C.; Figueiredo, Samy; Gaborit, Benjamin; Gaci, Rostane; Gagneux‐Brunon, Amandine; Gallien, Sébastien; Garot, Denis; Géri, Guillaume; Gibot, Sébastien; Goehringer, François; Gousseff, Marie; Gruson, Didier; Hansmann, Yves; Hinschberger, O.; Jauréguiberry, Stéphane; Jean-Michel, Vanessa; Kernéis, Solen; Kimmoun, Antoine; Klouche, Kada; Lachâtre, Marie; Lacombe, Karine; Laine, Fabrice; Lanoix, Jean‐Philippe; Launay, Odile; Laviolle, Bruno; Le Moing, Vincent; Le Pavec, Jérôme; Le Tulzo, Yves; Le Turnier, Paul; Lebeaux, David; Lefèvre, Benjamin; Leroy, Sylvie; Lescure, François‐Xavier; Lessire, Henry; Leveau, Benjamin; Loubet, Paul; Makinson, Alain; Malvy, Denis; Marquette, Charles‐Hugo; Martin‐Blondel, Guillaume; Martinot, M.; Mayaux, Julien; Mekontso Dessap, Armand; Meziani, Ferhat; Mira, Jean‐Paul; Molina, Jean‐Michel; Monnet, Xavier; Mootien, Joy; Mourvillier, Bruno; Murris‐Espin, M.; Navellou, Jean-Christophe; Nseir, Saad; Oulehri, Walid; Peiffer-Smadja, Nathan; Perpoint, Thomas; Pialoux, Gilles; Pilmis, Benoît; Piriou, Vincent; Piroth, Lionel; Poissy, Julien; Pourcher, Valérie; Quenot, Jean‐Pierre; Raffi, François; Reignier, Jean; Revest, Matthieu; Richard, Jean‐Christophe; Riu-Poulenc, Béatrice; Robert, Céline; Roger, Pierre-Alexandre; Roger, Claire; Rouveix-Nordon, Elisabeth; Ruch, Yvon; Saïdani, Nadia; Sayre, N.; Senneville, É.; Sotto, Albert; Stefan, Francois; Tacquard, Charles; Terzi, Nicolas; Textoris, Julien; Thiéry, Guillaume; Timsit, Jean‐François; Tolsma, Violaine; Turmel, Jean-Marie; Valour, Florent; Wallet, Florent; Wattecamps, Guilhem; Yazdanpanah, Yazdan; Zerbib, Yoann; J. Berna, Marc; Reuter, Jean; Staub, Thérèse; Braz, Sandra; Ferreira Ribeiro, Joao-Miguel; Paiva, José-Artur; Roncon‐Albuquerque, Roberto; Bouscambert-Duchamp, Maude; Gaymard, Alexandre; Lê, Minh-Patrick; Lina, Bruno; Peytavin, Gilles; Tubiana, Sarah; Couffin-Cadièrgues, Sandrine; Espérou, Hélène; Belhadi, Drifa; Burdet, Charles; Costagliola, Dominique; Dechanet, Aline; Delmas, Christelle; Diallo, Alpha; Fougerou, Claire; Guedj, Jérémie; Mentré, France; Mercier, Noémie; Noret, Marion; Saillard, Juliette; Velou, Priyanka

doi:10.1016/s1473-3099(21)00485-0

Public

Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial

Published in The Lancet Infectious Diseases • Sep 14, 2021

Authors:

Florence Ader

Maude Bouscambert-Duchamp

Abstract

BACKGROUND: The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial. We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with standard of care alone in patients admitted to hospital with COVID-19, with indication of oxygen or ventilator supp...

Subject

Coronavirus disease 2019 (COVID-19)

Standard of care

Medicine

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