Metal‐Polyphenol‐Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification

Zhou, Lulu; Chen, Jinjin; Li, Ruihao; Wei, Lizhen; Haitao, Xiong; Wang, Chunhui; Chai, Keke; Chen, Mengyao; Zhu, Zhounan; Yao, Tianming; Lin, Yun; Dong, Chunyan; Shi, Shuo

doi:10.1002/smll.202103919

Public

Metal‐Polyphenol‐Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification

Published in Small • Oct 8, 2021

Authors:

Lulu Zhou

Jinjin Chen

Ruihao Li

Abstract

Abstract Given that traditional anticancer therapies fail to significantly improve the prognoses of triple negative breast cancer (TNBC), new modalities with high efficiency are urgently needed. Herein, by mixing the metal‐phenolic network formed by tannic acid (TA), bleomycin (BLM), and Fe 3+ with ...

Subject

Prussian blue

Apoptosis

GPX4

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