Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification.

L, Zhou; J, Chen; R, Li; L, Wei; H, Xiong; C, Wang; K, Chai; M, Chen; Z, Zhu; T, Yao; Y, Lin; C, Dong; S, Shi

doi:10.1002/smll.202103919

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Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification.

Shared by NobleBlocks on Oct 8, 2021 • 12:00 AM UTC

Authors:

Zhou L

Chen J

Li R

Abstract

Given that traditional anticancer therapies fail to significantly improve the prognoses of triple negative breast cancer (TNBC), new modalities with high efficiency are urgently needed. Herein, by mixing the metal-phenolic network formed by tannic acid (TA), bleomycin (BLM), and Fe3+ with glutathion...

Subject

Prussian Blue

Ferroptosis

Synergistic Tumor Therapy

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