Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF‐<i>κ</i>B Suppression and NLRP3 Inflammasome Inhibition

Ran, Yuanyuan; Su, Wei; Gao, Fuhai; Ding, Zitong; Yang, Shui-Qing; Ye, Lin; Chen, Xuechai; Tian, Guiqin; Xi, Jianing; Liu, Zongjian

doi:10.1155/2021/1552127

Public

Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF‐κB Suppression and NLRP3 Inflammasome Inhibition

Published in Oxidative Medicine and Cellular Longevity • Jan 1, 2021

Authors:

Yuanyuan Ran

Wei Su

Fuhai Gao

Abstract

NLRP3 inflammasome‐mediated pyroptosis is a proinflammatory programmed cell death pathway, which plays a vital role in functional outcomes after stroke. We previously described the beneficial effects of curcumin against stroke‐induced neuronal damage through modulating microglial polarization. Howev...

Subject

Pyroptosis

Curcumin

Inflammasome

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