Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Eijsbouts, Chris; Zheng, Tenghao; A. Kennedy, Nicholas; Bonfiglio, Ferdinando; A. Anderson, Carl; Moutsianas, Loukas; Holliday, Jo; Shi, Jingchunzi; Shringarpure, Suyash; Agee, Michelle; Aslibekyan, Stella; Auton, Adam; K. Bell, Robert; Bryc, Katarzyna; Clark, Sarah; L. Elson, Sarah; Fletez‐Brant, Kipper; Fontanillas, Pierre; A. Furlotte, Nicholas; Gandhi, Pooja; Heilbron, Karl; Hicks, Barry; A. Hinds, David; E. Huber, Karen; M. Jewett, Ethan; Jiang, Yunxuan; Kleinman, Aaron; Lin, Keng‐Han; K. Litterman, Nadia; K. Luff, Marie; C. McCreight, Jey; H. McIntyre, Matthew; F. McManus, Kimberly; L. Mountain, Joanna; V. Mozaffari, Sahar; Nandakumar, Priyanka; S. Noblin, Elizabeth; A. M. Northover, Carrie; O’Connell, Jared; A. Petrakovitz, Aaron; J. Pitts, Steven; David Poznik, G.; Fah Sathirapongsasuti, J.; J. Shastri, Anjali; F. Shelton, Janie; Tian, Chao; Y. Tung, Joyce; J. Tunney, Robert; Vacic, Vladimir; Wang, Xin; S. Zare, Amir; Voda, Alexandru-Ioan; Bellygenes Initiative, The; Kashyap, Purna; Chang, Lin; A. Mayer, Emeran; Heitkemper, Margaret; S. Sayuk, Gregory; Ringel‐Kulka, Tamar; Ringel, Yehuda; D. Chey, William; Eswaran, Shanti; L. Merchant, Juanita; J. Shulman, Robert; Bujanda, Luís; García‐Etxebarria, Koldo; Dlugosz, Aldona; Lindberg, Greger; T. Schmidt, Peter; Karling, Pontus; Ohlsson, Bodil; Walter, Susanna; Faresjö, Åshild; Simrén, Magnus; Halfvarson, Jonas; Portincasa, Piero; Barbara, Giovanni; Usai–Satta, Paolo; Neri, Matteo; Nardone, Gerardo; Cuomo, Rosario; Galeazzi, Francesca; Bellini, Massimo; Latiano, Anna; A. Houghton, Lesley; Jonkers, Daisy; Kurilshikov, Alexander; K. Weersma, Rinse; G. Netea, Mihai; Tesarz, Jonas; Gauss, Annika; Goebel‐Stengel, Miriam; Andresen, Viola; Frieling, Thomas; Pehl, Christian; Schaefert, Rainer; Niesler, Beate; Lieb, Wolfgang; Hanevik, Kurt; Langeland, Nina; Wensaas, Knut‐Arne; Litleskare, Sverre; E. Gabrielsen, Maiken; F. Thomas, Laurent; Thijs, Vincent; Lemmens, Robin; Van Oudenhove, Lukas; M. Wouters, Mira; Farrugia, Gianrico; Franke, André; Hübenthal, Matthias; R. Abecasis, Gonçalo; Zawistowski, Matthew; Heidi Skogholt, Anne; Ness‐Jensen, Eivind; Hveem, Kristian; Esko, Tõnu; Teder‐Laving, Maris; Zhernakova, Alexandra; Camilleri, Michael; E. Boeckxstaens, Guy; J. Whorwell, Peter; E. Spiller, Robert; McVean, Gil; D’Amato, Mauro; Jostins-Dean, Luke; Parkes, Miles

doi:10.1038/s41588-021-00950-8

Public

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Published in Nature Genetics • Nov 1, 2021

Authors:

Chris Eijsbouts

Tenghao Zheng

Nicholas A. Kennedy

Abstract

Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent c...

Subject

Irritable bowel syndrome

Anxiety

Genome-wide association study

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