Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19

C. Spyropoulos, Alex; Goldin, Mark; Giannis, Dimitrios; Diab, Wassim; Wang, Janice; Khanijo, Sameer; Mignatti, Andrea; Gianos, Eugenia; Cohen, Marc; Sharifova, Gulru; Lund, J; Tafur, Alfonso; A. Lewis, Paul; P. Cohoon, Kevin; Rahman, Husneara; Sison, Cristina; Lesser, Martin; Ochani, Kanta; Agrawal, Nirav; Hsia, Judith; E. Anderson, Victoria; P. Bonaca, Marc; L. Halperin, Jonathan; I. Weitz, Jeffrey; Investigators, HEP-COVID; Ohanesian, Lori; Glater, Michelle; C.K. Ho, Christopher; Iakovou, Annamaria; Ying, Daniel; Dastagir, Manile; Convissar, Alex; Aujla, Seerat; Mathew, Elizabeth; Thiyagarajan, Vani; Lewis, Tricia; Gruberg, Luis; Maccaro, Paul; Kuziw, Dana; Pandhi, Bhumi; Surguladze, George; M. Eapen, Ashley; Pantea, A.; SUEN, PHYLLIS; P. Flynt, John; Krzyzak, Michael; Sharma, Kamal; Steadham, Amanda; McLean, Sherry; Herring, Karen; Maroney, Karen; Zorriasateyn, Kambiz; Vargas‐Leitón, Bernardo; Durante, Marisa; Bhokary, Ujala; Pierchala, Linda; A. Fisher, Elizabeth; L. Oxenberg, Debi; Sabados, Alison; A. Chaudhary, Omair; Schultz, Shelley; Cotey, S.; N. Hess, Connie; Cruse, Hope; Uy, Daniel; Sharma, Sunita; Molina, Kevin; Jagat, Daliya; Dehali, Bandyopadhyay

doi:10.1001/jamainternmed.2021.6203

Public

Efficacy and Safety of Therapeutic-Dose Heparin vs Standard Prophylactic or Intermediate-Dose Heparins for Thromboprophylaxis in High-risk Hospitalized Patients With COVID-19

Published in JAMA Internal Medicine • Oct 10, 2021

Authors:

Alex C. Spyropoulos

Mark Goldin

Dimitrios Giannis

Abstract

Importance: Hospitalized patients with COVID-19 are at risk for venous and arterial thromboembolism and death. Optimal thromboprophylaxis dosing in high-risk patients is unknown. Objective: To evaluate the effects of therapeutic-dose low-molecular-weight heparin (LMWH) vs institutional standard prop...

Subject

Medicine

Heparin

Coronavirus disease 2019 (COVID-19)

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