A prenylated dsRNA sensor protects against severe COVID-19

Wickenhagen, Arthur; Sugrue, Elena; Lytras, Spyros; Kuchi, Srikeerthana; Noerenberg, Marko; L. Turnbull, Matthew; Loney, Colin; Herder, Vanessa; Allan, Jay; Jarmson, Innes; Cameron-Ruiz, Natalia; Varjak, Margus; Maria Pinto, Rute; Seok Lee, Young; Iselin, Louisa; Palmalux, Natasha; G. Stewart, Douglas; Swingler, Simon; JD Greenwood, Edward; W. M. Crozier, Thomas; Gu, Quan; L. Davies, Emma; Clohisey, Sara; Wang, Bo; Trindade Maranhão Costa, Fábio; Freire Santana, Monique; Carlos de Lima Ferreira, Luíz; Murphy, Lee; Fawkes, Angie; Meynert, Alison; R. Grimes, Graeme; Investigators, ISARIC4C; Luiz Silva‐Filho, João; Marti, Matthias; Hughes, Joseph; J. Stanton, Richard; C. Y. Wang, Eddie; Ho, Antonia; Davis, Ilan; F. Jarrett, Ruth; Castelló, Alfredo; L. Robertson, David; G. Semple, Malcolm; J. M. Openshaw, Peter; Palmarini, Massimo; J. Lehner, Paul; Kenneth Baillie, J.; J. Rihn, Suzannah; J. Wilson, Sam

doi:10.1126/science.abj3624

Public

A prenylated dsRNA sensor protects against severe COVID-19

Published in Science • Sep 28, 2021

Authors:

Arthur Wickenhagen

Elena Sugrue

Spyros Lytras

Abstract

Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and reduce disease severity. To better understand the antiviral defenses releva...

Subject

Prenylation

Biology

Coronavirus

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!