A prenylated dsRNA sensor protects against severe COVID-19

Wickenhagen, Arthur; Sugrue, Elena; Lytras, Spyros; Kuchi, Srikeerthana; Noerenberg, Marko; L. Turnbull, Matthew; Loney, Colin; Herder, Vanessa; Allan, Jay; Jarmson, Innes; Cameron-Ruiz, Natalia; Varjak, Margus; M. Pinto, Rute; Y. Lee, Jeffrey; Iselin, Louisa; Palmalux, Natasha; G. Stewart, Douglas; Swingler, Simon; J. D. Greenwood, Edward; W. M. Crozier, Thomas; Gu, Quan; L. Davies, Emma; Clohisey, Sara; Wang, Bo; Trindade Maranhão Costa, Fabio; Freire Santana, Monique; Carlos de Lima Ferreira, Luiz; Murphy, Lee; Fawkes, Angie; Meynert, Alison; Grimes, Graeme; Investigators, ISARIC4C; Luiz Da Silva Filho, Joao; Marti, Matthias; Hughes, Joseph; J. Stanton, Richard; C. Y. Wang, Eddie; Ho, Antonia; Davis, Ilan; F. Jarrett, Ruth; Castello, Alfredo; L. Robertson, David; G. Semple, Malcolm; J. M. Openshaw, Peter; Palmarini, Massimo; J. Lehner, Paul; Kenneth Baillie, J.; J. Rihn, Suzannah; J. Wilson, Sam

doi:10.1126/science.abj3624

Public

A prenylated dsRNA sensor protects against severe COVID-19

Shared by NobleBlocks on Oct 28, 2021 • 12:00 AM UTC

Authors:

Arthur Wickenhagen

Elena Sugrue

Spyros Lytras

Abstract

The bat connection The heterogeneity of COVID-19 makes it challenging to predict the course of infection in an individual. Upon virus infection, interferons (IFNs) generate the initial signals for cellular defenses. Knowing that defects in IFN signaling are associated with more severe COVID-19, Wick...

Discussions