Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence

Moody, Sarah; Senkin, S.; M. Ashiqul Islam, S.; Wang, Jingwei; Nasrollahzadeh, Dariush; Cortez Cardoso Penha, Ricardo; Fitzgerald, Stephen; N. Bergstrom, Erik; Atkins, Joshua; He, Yudou; Khandekar, Azhar; Smith-Byrne, Karl; Carreira, Christine; Gaborieau, Valérie; Latimer, Calli; Thomas, Emily; Abnizova, Irina; E. Bucciarelli, Pauline; Jones, David; W. Teague, Jon; Abedi‐Ardekani, Behnoush; Serra, Stefano; Scoazec, Jean‐Yves; Saffar, Hiva; Azmoudeh Ardalan, Farid; Sotoudeh, Masoud; Nikmanesh, Arash; Poustchi, Hossein; Niavarani, Ahmadreza; Gharavi, Samad; Edén, Michael; Richman, Paul; S. Campos, Lia; C. Fitzgerald, Rebecca; Felipe Ribeiro, Luis; Coelho Soares‐Lima, Sheila; P. Dzamalala, Charles; T. Mmbaga, Blandina; Shibata, Tatsuhiro; Menya, Diana; M. Goldstein, Alisa; Hu, Nan; Malekzadeh, Reza; Fazel, Abdolreza; McCormack, Valerie; McKay, James; Pérdomo, Sandra; Scélo, Ghislaine; Chanudet, Estelle; Humphreys, Laura; B. Alexandrov, Ludmil; Brennan, Paul; R. Stratton, Michael

doi:10.1038/s41588-021-00928-6

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Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence

Published in Nature Genetics • Oct 18, 2021

Authors:

Sarah Moody

S. Senkin

S. M. Ashiqul Islam

Abstract

Esophageal squamous cell carcinoma (ESCC) shows remarkable variation in incidence that is not fully explained by known lifestyle and environmental risk factors. It has been speculated that an unknown exogenous exposure(s) could be responsible. Here we combine the fields of mutational signature analy...

Subject

Biology

Incidence (geometry)

Esophageal squamous cell carcinoma

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