Efficacy of typhoid conjugate vaccine in Nepal: final results of a phase 3, randomised, controlled trial

Shakya, Mila; Voysey, Merryn; Theiss-Nyland, Katherine; Colin-Jones, Rachel; Pant, Dikshya; Adhikari, Anup; Tonks, Susan; F Mujadidi, Yama; O’Reilly, Peter; Mazur, Olga; Kelly, Sarah; Liu, Xinxue; Maharjan, Archana; Dahal, Ashata; Haque, Naheeda; Pradhan, Anisha; Shrestha, Suchita; Joshi, Manvi; Smith, Nicola; Hill, Jennifer; Clarke, Jenny; Stockdale, Lisa; Jones, Elizabeth; Lubinda, Timothy; Bajracharya, Binod; Dongol, Sabina; Karkey, Abhilasha; Baker, Stephen; Dougan, Gordan; E. Pitzer, Virginia; M. Neuzil, Kathleen; Shrestha, Shrijana; Basnyat, Buddha; J. Pollard, Andrew

doi:10.1016/s2214-109x(21)00346-6

Public

Efficacy of typhoid conjugate vaccine in Nepal: final results of a phase 3, randomised, controlled trial

Published in The Lancet Global Health • Oct 22, 2021

Authors:

Mila Shakya

Merryn Voysey

Katherine Theiss-Nyland

Abstract

BACKGROUND: Typhoid fever is a major public health problem in low-resource settings. Vaccination can help curb the disease and might reduce transmission. We have previously reported an interim analysis of the efficacy of typhoid conjugate vaccine (TCV) in Nepali children. Here we report the final re...

Subject

Typhoid fever

Medicine

Vaccination

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