Disrupted intrinsic functional brain topology in patients with major depressive disorder

Yang, Hong; Chen, Xiao; Chen, Zuo-Bing; Li, Le; Li, Xue-Ying; Xavier Castellanos, F.; Bai, Tong-Jian; Bo, Qi-Jing; Cao, Jun; Chang, Zhi-Kai; Chen, Guan-Mao; Chen, Ning-Xuan; Chen, Wei; Chang, Cheng; Cheng, Yu-Qi; Cui, Xi-Long; Duan, Jia; Fang, Yiru; Gong, Qiyong; Guo, Wen-Bin; Hou, Zheng-Hua; Hu, Lan; Kuang, Li; Li, Feng; Li, Hui-Xian; Li, Kai-Ming; Li, Tao; Liu, Yan-Song; Liu, Zhe-Ning; Long, Yicheng; Lu, Bin; Luo, Qing-Hua; Meng, Hua-Qing; Peng, Daihui; Qiu, Hai-Tang; Qiu, Jiang; Shen, Yue-Di; Shi, Yu-Shu; Si, Tian-Mei; Tang, Yan-Qing; Wang, Chuanyue; Wang, Fei; Wang, Kai; Wang, Li; Wang, Xiang; Wang, Ying; Wang, Yuwei; Wu, Xiao-Ping; Wu, Xin-Ran; Xie, Chunming; Xie, Guang-Rong; Xie, Hai-Yan; Xie, Peng; Xu, Xiu-Feng; Yang, Jian; Yao, Jia-Shu; Yao, Shu-Qiao; Yin, Ying-Ying; Yuan, Yonggui; Zang, Yu‐Feng; Zhang, Ai-Xia; Zhang, Hong; Zhang, Ke-Rang; Zhang, Lei; Zhang, Zhijun; Zhao, Jing-Ping; Zhou, Rubai; Zhou, Yi; Zhu, Jun-Juan; Zhu, Zhi-Chen; Zou, Chao‐Jie; Zuo, Xi‐Nian; Yan, Chao‐Gan

doi:10.1038/s41380-021-01247-2

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Disrupted intrinsic functional brain topology in patients with major depressive disorder

Published in Molecular Psychiatry • Aug 12, 2021

Authors:

Hong Yang

Xiao Chen

Zuo-Bing Chen

Abstract

Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, we utilized a big data sample of MDD patients from the REST-meta-MDD Project, including 821 ...

Subject

Major depressive disorder

Default mode network

Functional connectivity

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