NLRP3 inflammasome activation triggers gasdermin D–independent inflammation

Wang, Chun; Yang, Tong; Xiao, Jianqiu; Xu, Canxin; Alippe, Yael; Sun, Kai; Kanneganti, Thirumala‐Devi; B. Monahan, Joseph; Abu‐Amer, Yousef; Lieberman, Judy; Mbalaviele, Gabriel

doi:10.1126/sciimmunol.abj3859

Public

NLRP3 inflammasome activation triggers gasdermin D–independent inflammation

Published in Science Immunology • Oct 23, 2021

Authors:

Chun Wang

Tong Yang

Jianqiu Xiao

Abstract

mice. Thus, NLRP3 inflammasome activation overwhelms the protection afforded by GSDMD deficiency, rewiring signaling cascades through mechanisms that include GSDME to propagate inflammation.

Subject

Inflammasome

Pyroptosis

AIM2

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