Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury

Jiao, Yang; Zhang, Ti; Zhang, Chengmi; Ji, Haiying; Tong, Xingyu; Ran, Xia; Wang, Wei; Ma, Zhengliang; Shi, Xueyin

doi:10.1186/s13054-021-03775-3

Public

Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury

Published in Critical Care • Oct 12, 2021

Authors:

Yang Jiao

Ti Zhang

Chengmi Zhang

Abstract

BACKGROUND: Polymorphonuclear neutrophils (PMNs) play an important role in sepsis-related acute lung injury (ALI). Accumulating evidence suggests PMN-derived exosomes as a new subcellular entity acting as a fundamental link between PMN-driven inflammation and tissue damage. However, the role of PMN-...

Subject

Pyroptosis

Medicine

Macrophage polarization

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