Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Payne, Rebecca; Longet, Stephanie; Austin, James; Skelly, Donal; Dejnirattisai, Wanwisa; Adele, Sandra; Meardon, Naomi; Faustini, Sian; Al‐Taei, Saly; C. Moore, Shona; Tipton, Tom; M. Hering, Luisa; Angyal, Adrienn; Brown, Rebecca; R. Nicols, Alexander; Gillson, Natalie; L. Dobson, Susan; Amini, Ali; Supasa, Piyada; Cross, Andrew; Bridges-Webb, Alice; Silva-Reyes, Laura; Linder, Aline; Sandhar, Gurjinder; A. Kilby, Jonathan; K. Tyerman, Jessica; Altmann, Thomas; Hornsby, Hailey; Whitham, Rachel; Phillips, Eloise; Malone, Tom; Hargreaves, Alexander; Shields, Adrian; Saei, Ayoub; Foulkes, Sarah; Stafford, Lizzie; A. Johnson, Síle; Wootton, Dan; P. Conlon, Christopher; Jeffery, Katie; C. Matthews, Philippa; Frater, John; Deeks, Alexandra; J. Pollard, Andrew; Brown, Anthony; Rowland‐Jones, Sarah; Mongkolsapaya, Juthathip; Barnes, Eleanor; Hopkins, Susan; Hall, Victoria; Dold, Christina; Duncan, C.J.; Richter, Alex; W. Carroll, Miles; Screaton, Gavin; I. de Silva, Thushan; Turtle, Lance; Klenerman, Paul; Dunachie, Susanna; Abuelgasim, Hibatullah; Adland, Emily; Adlou, Syed; Delowar Akther, Hossain; Alhussni, Ahmed; Ali, Mohammad; Azim Ansari, M.; V. Arancibia-Cárcamo, Carolina; Bayley, Martin; Brown, Helen; Chalk, Jeremy; Chand, Meera; Chawla, Anu; Chinnakannan, Senthil; Cutteridge, Joseph; de Lara, Catherine; Denly, Lucy; L. Diffey, B.; Dimitriadis, Stavros; M Drake, Thomas; Donnison, Timothy; Dupont, Maeva; W. Eyre, David; Fairman, Alex; Gardiner, Siobhan; Gilbert-Jarmillo, Javier; Goulder, Philip; Hackstein, Carl-Philipp; Hambleton, Sophie; Haniffa, Muzlifah; Haworth, Jenny; Holmes, Jennifer; C. Horner, Emily; Jämsén, Anni; A. Johnson, Síle; R. Jones, Christopher; Kasanyinga, Mwila; Kelly, Sinéad; Kirk, Rosemary; L. Knight, Michael; Lawrie, Allan; Ni Lee, Lian; Lett, Lauren; Lillie, Katy; Lim, Nicholas; Mehta, Hema; J. Mentzer, Alexander; O’Donnell, Denise; Ogbe, Ane; Pace, Matthew; Payne, Brendan; Platt, Gareth; Poolan, Sonia; M. Provine, Nicholas; Ramamurthy, Narayan; Robinson, Nichola; Romaniuk, Leigh; Rongkard, Patpong; Sampson, Oliver; Simmons, Beatrice; Stremenova Spegarova, Jarmila; Stephenson, Emily; Subramaniam, Kris; Thaventhiran, James; Thomas, Sarah; Travis, Simon; Tucker, Stephanie; Turton, H.; Watson, Adam; Watson, Lisa; Weeks, Esme; Wilson, Robert; C. Wood, Steven; Wright, Rachel; Xiao, Huiyuan; Zawia, Amira

doi:10.1016/j.cell.2021.10.011

Public

Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine

Published in Cell • Oct 18, 2021

Authors:

Rebecca Payne

Stephanie Longet

James Austin

Abstract

Highlights d BNT162b2 vaccine with an extended interval between doses is highly protective d Antibody levels were higher after the extended regimen compared with the short regimen d The extended regimen enriches for virus-specific CD4 + T cells expressing IL-2 d Antibody levels wane after each dose,...

Subject

Immunogenicity

Dosing

Biology

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