The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Wenzel, Jan; Lampe, Josephine; Müller‐Fielitz, Helge; Schuster, Raphael; Zille, Marietta; Müller, K.-M.; Krohn, Markus; Körbelin, Jakob; Zhang, Linlin; Özorhan, Ümit; Neve, Vanessa; U. G. Wagner, Julian; Bojková, Denisa; Shumliakivska, Mariana; Jiang, Yun; Fähnrich, Anke; Ott, Fabian; Sencio, Valentin; Robil, Cyril; Pfefferle, Susanne; Sauvé, Florent; Fernando Ferreira Coêlho, Caio; Franz, Jonas; Spiecker, Frauke; Lembrich, Beate; Binder, Sonja; Feller, Nina; König, Peter; Busch, Hauke; Collin, Ludovic; Villaseñor, Roberto; Jöhren, Olaf; C. Altmeppen, Hermann; Pasparakis, Manolis; Dimmeler, Stefanie; Činátl, Jindřich; Püschel, Klaus; Zelic, Matija; Ofengeim, Dimitry; Stadelmann, Christine; Trottein, François; Nogueiras, Rubén; Hilgenfeld, Rolf; Glatzel, Markus; Prévot, Vincent; Schwaninger, Markus

doi:10.1038/s41593-021-00926-1

Public

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Published in Nature Neuroscience • Oct 21, 2021

Authors:

Jan Wenzel

Josephine Lampe

Helge Müller‐Fielitz

Abstract

Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms underlying the vascular pathology. In brains of severe acute resp...

Subject

Neuropathology

Pathology

Biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!