Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis

Xu, Shujun; Wu, Bingxin; Zhong, Biying; Lin, Luoqi; Ding, Yining; Jin, Xiao; Huang, Zhiwei; Lin, Miaoyang; Wu, Huanlin; Xu, Danping

doi:10.1080/21655979.2021.1995994

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Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis

Published in Bioengineered • Oct 26, 2021

Authors:

Shujun Xu

Bingxin Wu

Biying Zhong

Abstract

Ferroptosis is an important form of myocardial cell death in myocardial ischemia-reperfusion injury (MIRI). Naringenin (NAR), as a flavonoid, has a significant advantage in improving MIRI. But the regulatory effect and mechanism of NAR on ferroptosis in MIRI have not been reported. After the rats we...

Subject

GPX4

Oxidative stress

Naringenin

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