RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

George, Jasmine; Li, Yongsheng; P. Kadamberi, Ishaque; Parashar, Deepak; Tsaih, Shirng-Wern; Gupta, Prachi; Geethadevi, Anjali; Chen, Changliang; Ghosh, Chandrima; Sun, Yunguang; Mittal, Sonam; Ramchandran, Ramani; Rui, Hallgeir; Lopez‐Berestein, Gabriel; Rodriguez‐Aguayo, Cristian; Leone, Gustavo; S. Rader, Janet; K. Sood, Anil; Dey, Madhusudan; Pradeep, Sunila; Chaluvally–Raghavan, Pradeep

doi:10.1016/j.celrep.2021.109934

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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

Published in Cell Reports • Nov 1, 2021

Authors:

Jasmine George

Yongsheng Li

Ishaque P. Kadamberi

Abstract

Fragile X-related protein-1 (FXR1) gene is highly amplified in patients with ovarian cancer, and this amplification is associated with increased expression of both FXR1 mRNA and protein. FXR1 expression directly associates with the survival and proliferation of cancer cells. Surface sensing of trans...

Subject

Translation (biology)

Protein biosynthesis

RNA-binding protein

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