Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer

Fokas, Emmanouil; Schlenska‐Lange, Anke; Polat, Bülent; Klautke, Günther; G. Grabenbauer, Gerhard; Fietkau, Rainer; Kuhnt, Thomas; Staib, Ludger; Brunner, Thomas; Grosu, Anca‐Ligia; Kirste, Simon; Jacobasch, Lutz; Allgäuer, Michael; Flentje, Michael; Germer, Christoph‐Thomas; Grützmann, Robert; Hildebrandt, Guido; Schwarzbach, Matthias; O. Bechstein, Wolf; Sülberg, Heiko; Friede, Tim; Gaedcke, Jochen; Ghadimi, Michael; Hofheinz, Ralf‐Dieter; Rödel, Claus; Rectal Cancer Study Group, German; Imhoff, Detlef; Woeste, Guido; Habbe, Nils; Pession, Ursula; Hansmann, Martin‐Leo; J. Wild, Peter; Falk, Stephan; Hödl, Petra; Serebrennikov, A; Schmeck, Sanja; Paolucci, Vittorio; Sahm, Stephan; Eichel, Martin; Römer, Giovanna; Bank, W.; Moosmann, Nicolas; Braess, Jan; Piso, P.; Wiesinger, Heinrich; Kappl, Peter; Germer, Elisabeth; Warmuth‐Metz, Monika; Kunzmann, Volker; Krajinovic, Katica; Rosenwald, Andreas; Alexander Bley, Thorsten; Stölzel, Ulrich; Dörne, Manfred; Renziehausen, L.; Boese-Land, Joachim; Meißner, Dietrich; Burchert, D.; Dirsch, Olaf; Olaf Habeck, Jörg; Kirchhof, Klaus; Lamberti, Christof; J. Leibl, B.; Gschwendtner, Andreas; Lahmer, Godehard; Lang-Welzenbach, Marga; Hohenberger, Werner; Kuhnt, Thomas; Papsdorf, Kirsten; Wittekind, Christian; Volkheimer, Christine; Wenz, Frederik; Merx, Kirsten; Post, Stefan; Gaiser, Timo; Attenberger, Ulrike; Geißler, Michael; Sträter, Jörn; Gnann, Helmut; Krämer, Stefan; Henke, Michael; Schäfer, Henning; Manegold, Philipp; Neeff, Hannes; Bronsert, Peter; Schmiegel, Wolff; Pohl, Michael; Möllecken, Christian; us A. Adamietz, Irenä; Viehbahn, Richard; Tannapfel, Andrea; Freiberg‐Richter, Jens; Jacobi, Thorsten; Wendt, Wolfgang; Holzweißig, Klaus; Kittner, Thomas; Graeven, Ullrich; Lange, Christiane; Kania, U.; Rösler, Elisabeth; Ortloff, Harold; Müller-Leisse, C.; Folprecht, Gunnar; Ubbelohde, Ulrike; Baretton, Gustavo; Kölbl, Oliver; Steger, Felix; Hofstädter, Ferdinand; J. Schlitt, Hans; Stroszczynski, Christian; Binnebösel, Marcel; J. Eble, Michael; Lüdde, Tom; Knüchel‐Clarke, Ruth; Bruners, Philipp; Küchenmeister, Ute; Klar, Ernst; Erbesdolber, Andreas; Halm, Ulrich; Zachäus, Markus; Schneider, Eckhardt; Schmidt, Thomas; Köhne, Claus‐Henning; Rosin, Bernd; Willborn, Kay; Henke, Rolf‐Peter; Griesinger, Frank; Zwenneke Flach, H.

doi:10.1001/jamaoncol.2021.5445

Public

Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer

Published in JAMA Oncology • Nov 18, 2021

Authors:

Emmanouil Fokas

Anke Schlenska‐Lange

Bülent Polat

Abstract

IMPORTANCE: Total neoadjuvant therapy has been increasingly adopted for multimodal rectal cancer treatment. The optimal sequence of chemoradiotherapy (CRT) and chemotherapy needs to be established. OBJECTIVE: To report the long-term results of the secondary end points prespecified in the Randomized ...

Subject

Medicine

Oxaliplatin

Total mesorectal excision

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