SIRT6 protects vascular smooth muscle cells from osteogenic transdifferentiation via Runx2 in chronic kidney disease

Li, Wenxin; Feng, Weijing; Su, Xiaoyan; Luo, Dongling; Li, Zhibing; Zhou, Yongqiao; Zhu, Yongjun; Zhang, Mengbi; Chen, Jie; Liu, Baohua; Huang, Hui

doi:10.1172/jci150051

Public

SIRT6 protects vascular smooth muscle cells from osteogenic transdifferentiation via Runx2 in chronic kidney disease

Published in Journal of Clinical Investigation • Nov 18, 2021

Authors:

Wenxin Li

Weijing Feng

Xiaoyan Su

Abstract

Vascular calcification (VC) is regarded as an important pathological change lacking effective treatment and associated with high mortality. Sirtuin 6 (SIRT6) is a member of the Sirtuin family, a class III histone deacetylase and a key epigenetic regulator. SIRT6 has a protective role in patients wit...

Subject

Transdifferentiation

SIRT6

Vascular smooth muscle

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