Impaired Functional T-Cell Response to SARS-CoV-2 After Two Doses of BNT162b2 mRNA Vaccine in Older People

Demaret, Julie; Corroyer-Simovic, Bénédicte; Kazali Alidjinou, Enagnon; Goffard, Anne; Trauet, Jacques; Miczek, Sophie; Vuotto, Fanny; Dendooven, Arnaud; Huvent‐Grelle, Dominique; Podvin, Juliette; Dreuil, Daniel; Faure, Karine; Deplanque, Dominique; Bocket, Laurence; Duhamel, Alain; Labreuche, Julien; Sobaszek, Annie; Hisbergues, Michael; Puisieux, François; Labalette, Myriam; Lefèvre, Guillaume

doi:10.3389/fimmu.2021.778679

Public

Impaired Functional T-Cell Response to SARS-CoV-2 After Two Doses of BNT162b2 mRNA Vaccine in Older People

Published in Frontiers in Immunology • Nov 16, 2021

Authors:

Julie Demaret

Bénédicte Corroyer-Simovic

Enagnon Kazali Alidjinou

Abstract

Long-term care facility (LTCF) older residents display physiological alterations of cellular and humoral immunity that affect vaccine responses. Preliminary reports suggested a low early postvaccination antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The aim o...

Subject

Immunosenescence

ELISPOT

Medicine

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