PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis

Li, Zhongwei; Wang, Diandian; Chen, Xintian; Wang, Wenwen; Wang, Pengfei; Hou, Pingfu; Li, Minle; Chu, Sufang; Qiao, Shuxi; Zheng, Junnian; Bai, Jin

doi:10.1038/s41419-021-04381-5

Public

PRMT1-mediated EZH2 methylation promotes breast cancer cell proliferation and tumorigenesis

Published in Cell Death and Disease • Nov 13, 2021

Authors:

Zhongwei Li

Diandian Wang

Xintian Chen

Abstract

Protein arginine methyltransferase 1 (PRMT1) is able to promote breast cancer cell proliferation. However, the detailed mechanisms of PRMT1-mediated breast cancer cell proliferation are largely unknown. In this study, we reveal that PRMT1-mediated methylation of EZH2 at the R342 site (meR342-EZH2) h...

Subject

Carcinogenesis

Methylation

EZH2

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