Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device

M. James Shapiro, A.; Thompson, David; Donner, Thomas; D. Bellin, Melena; A. Hsueh, Willa; Pettus, Jeremy; S. Wilensky, Jon; Daniels, Mark; M. Wang, Richard; P. Brandon, Eugene; S. JAIMAN, MANASI; Kroon, Evert; A. D’Amour, Kevin; L. Foyt, Howard

doi:10.1016/j.xcrm.2021.100466

Public

Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device

Published in Cell Reports Medicine • Dec 1, 2021

Authors:

A. M. James Shapiro

David Thompson

Thomas Donner

Abstract

These preliminary data from an ongoing first-in-human phase 1/2, open-label study provide proof-of-concept that pluripotent stem cell-derived pancreatic endoderm cells (PEC-01) engrafted in type 1 diabetes patients become islet cells releasing insulin in a physiologically regulated fashion. In this ...

Subject

Induced pluripotent stem cell

Stem cell

Medicine

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