The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

El Bairi, Khalid; R. Haynes, Harry; F. Blackley, Elizabeth; Fineberg, Susan; Shear, Jeffrey; Turner, Sophia; Ribeiro de Freitas, Juliana; Sur, Daniel; Claudio Amendola, Luis; Gharib, Masoumeh; Kallala, Amine; Arun, Indu; Azmoudeh Ardalan, Farid; Botinelly Mendonça Fujimoto, Luciana; F. Sua, Luz; Liu, Shiwei; Lien, Huang‐Chun; Kirtani, Pawan; Balancin, Marcelo; El Attar, H.; Guleria, Prerna; Yang, Wenxian; Shash, Emad; Chen, I‐Chun; Bautista, Verónica; Fernando do Prado Moura, José; L. Rapoport, Bernardo; Castaneda, Carlos; Spengler, Eunice; Acosta-Haab, Gabriela; Frahm, Isabel; Sanchez, Joselyn; Castillo, Miluska; Bouchmaa, Najat; R. Md Zin, Reena; Shui, Ruohong; Onyuma, Timothy; Yang, Wentao; Husain, Zaheed; Willard‐Gallo, Karen; Coosemans, An; Perez, Edith; Provenzano, Elena; Gonzalez Ericsson, Paula; Richardet, Eduardo; Mehrotra, Ravi; Sarancone, Sandra; Ehinger, Anna; L. Rimm, David; M.S. Bartlett, John; Viale, Giuseppe; Denkert, Carsten; I. Hida, Akira; Sotiriou, Christos; Loibl, Sibylle; M. Hewitt, Stephen; Badve, Sunil; Fraser Symmans, W.; S. Kim, Rim; Pruneri, Giancarlo; Goel, Shom; A. Francis, Prudence; Inurrigarro, Gloria; Yamaguchi, Rin; Garcı́a Rivello, Hernán; M. Horlings, Hugo; Afqir, Saïd; Salgado, Roberto; Adams, Sylvia; Kok, Marleen; Vittoria Dieci, Maria; Michiels, Stefan; Demaria, Sandra; Loi, Sherene; International Immuno-Oncology Biomarker Working Group, The; El Bairi, Khalid; R. Haynes, Harry; F. Blackley, Elizabeth; Fineberg, Susan; Shear, Jeffrey; Turner, Sophia; Ribeiro de Freitas, Juliana; Sur, Daniel; Claudio Amendola, Luis; Gharib, Masoumeh; Kallala, Amine; Arun, Indu; Azmoudeh-Ardalan, Farid; Botinelly Mendonça Fujimoto, Luciana; F. Sua, Luz; Liu, Shiwei; Lien, Huang‐Chun; Kirtani, Pawan; Balancin, Marcelo; El Attar, Hicham; Guleria, Prerna; Yang, Wenxian; Shash, Emad; Chen, I‐Chun; Bautista, Veronica; Fernando Do Prado Moura, Jose; L. Rapoport, Bernardo; Castaneda, Carlos; Spengler, Eunice; Acosta‐Haab, Gabriela; Frahm, Isabel; Sanchez, Joselyn; Castillo, Miluska; Bouchmaa, Najat; R. Md Zin, Reena; Shui, Ruohong; Onyuma, Timothy; Yang, Wentao; Husain, Zaheed; Willard‐Gallo, Karen; Coosemans, An; Perez, Edith; Provenzano, Elena; Gonzalez Ericsson, Paula; Richardet, Eduardo; Mehrotra, Ravi; Sarancone, Sandra; Ehinger, Anna; L. Rimm, David; M. S. Bartlett, John; Viale, Giuseppe; Denkert, Carsten; I. Hida, Akira; Sotiriou, Christos; Loibl, Sibylle; M. Hewitt, Stephen; Badve, Sunil; Fraser Symmans, William; S. Kim, Rim; Pruneri, Giancarlo; Goel, Shom; A. Francis, Prudence; Inurrigarro, Gloria; Yamaguchi, Rin; Garcı́a Rivello, Hernán; Horlings, Hugo; Afqir, Saïd; Salgado, Roberto; Adams, Sylvia; Kok, Marleen; Vittoria Dieci, Maria; Michiels, Stefan; Demaria, Sandra; Loi, Sherene; Schelfhout, Vera; Arbzadeh, Elham; Bondanar, Anastasiya; Antonio Galeano Reyes, Silvio; Ramírez Ruz, José; Kang, Jun; Lü, Xiang; Zimovjanová, Martina; Togores, Pilar; Öztürk, Tülin; Patil, Asawari; Corpa, Marcus; Whitehouse, Ann; Tan, Benjamin; de Paula, Alfredo; Rossetti, Claudia; Lang‐Schwarz, Corinna; Mahon, Sarah; Giacometti, Cinzia; Linderholm, Barbro; Deman, Frederik; Montagna, Giacomo; Gong, Gyungyub; Pavcovich, Marta; Chaer, Yeesoo; Alvarado Cabrero, Isabel; Lopes de Brito, Mayana; Ilieva, Nevena; Fulop, Annamaria; Priscilla de Souza, Maiara; Bilancia, Domenico; Idowu, Michael; Johri, Ritika; Szpor, Joanna; Bachani, Lira; Schmitt, Fernando; Giannotti, Mag; Kurebayashi, Yutaka; Elias Anota Ramirez, Bruno; Salido, Eduardo; Bortesi, Laura; Bonetto, Sara; Elomina, Kevin; López, Patricia; Sharma, Vijay; Edirisinghe, Amalika; Mathur, Dhanvi; Sahay, Ayushi; Ait Mouloud, Makhlouf; Giang, Chau; Mukolwe, Edwin; Kiruka, Edgar; L. Samberg, Nancy; Abe, Norie; Brown, Mark; K.A. Millar, Ewan; Li, Xiaoxian; Zheng, Yuan; Pasupathy, Asokan; Miele, Raffaele; D. Luff, Ronald; Modesto Araújo e Porfírio, Mônica; Ajemba, Ogugua; Soni, Rashida; Orvieto, Enrico; DiMaio, Michael; Thomas, Jeremy; Merard, Reena; Mani Subramaniam, Manish; Apolinario, Thiago; Preda, Ovidiu; Preda, Ricardo; Makanga, Alexander; do Rego Maciel Souto Maior, Marcelo; Li, Lingyu; Saghatchian, Mahasti; Saurine, Tricia; A. M. Janssen, Emiel; H. Cochran, John; Vlada, Nikitina; Cappellesso, Rocco; Elfer, Katherine; Hollick, Morven; Desai, Sangeeta; Öner, Gizem; J. M. Schreurs, A.; Liu, Steve; Perera, Rashindrie; Mercurio, Paola; Garcia, Felip; Hosny, Kareem; Matsumoto, Hirofumi; van Deurzen, Carolien; Bianchini, Giampaolo; Çoban, İpek; Jahangir, Arif; Rahman, Arman; G. 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Souza, Sandra; Cebollero, MarÇða; Felip, E.; Luis Solorzano Rendon, Jose; El Gabry, Ehab; Saltz, Joel; Bria, Emilio; Garufi, Giovanna; Hartman, Johan; Sebastian, Manu; Olofsson, Helena; Kooreman, Loes; Cucherousset, Joël; Mathieu, Marie‐Christine; Ballesteros‐Merino, Carmen; Siziopikou, Popi; J Fong, Jacinta; Klein, Molly; Roig I. Qulis, Ignasi; Wesseling, Jelle; Bellolio, Enrique; Carlos Araya, Juan; P. Naber, Stephen; Cheang, Maggie; Castellano, Isabella; Ales, Ales; Lænkholm, Anne‐Vibeke; Kulka, Janina; Quinn, Cecily; Sapino, Anna; Amendoeira, Isabel; Marchiò, Caterina; Braybrooke, Jeremy; Vincent-Salomon, Anne; Korski, Konstanty; Sofopoulos, Michail; Ida Specht Stovgaard, Elisabeth; Bianchi, Simonetta; Bagó-Horváth, Zsuzsanna; Yu, Clare; Regitnig, Peter; R. R. Hall, Sean; Kos, Zuzana; Sant, Sneha; Tille, Jean‐Christophe; D. Gallas, Brandon; Bethmann, Daniel; Savas, Peter; Mendes, Larissa; Soler, Teresa; van Seijen, Maartje; Gruosso, Tina; Quintana, Angela; M. Giltnane, Jennifer; Van den Eynden, Gert; Duregon, Eleonora; de Cabo, Rafael; Coates Recamo, Phil; Gaboury, Louis; Zimmerman, Johannes; Stanciu Pop, C.; Wernicke, Alejandra; Williams, David; J. Gill, Anthony; Solomon, Benjamin; Thapa, Bibhusal; Farshid, Gelareh; Gilham, Leslie; Christie, Michael; A. O’Toole, Sandra; Hendry, Shona; B. Fox, Stephen; J. Luen, Stephen; R. Lakhani, Sunil; L. Fuchs, Talia; John, Tom; Brčić, Iva; A. Hainfellner, Johannes; Lax, Sigurd; Preusser, Matthias; Poortmans, Philip; Decaluwe, Alex; Carey, Caroline; Colpaert, Cécile; Larsimont, Denis; Peeters, Dieter; Broeckx, Glenn; Van de Vijver, Koen; Buisseret, Laurence; Dirix, Luc; Hertoghs, Marjan; Piccart, Martine; Ignatiadis, Michail; Van Bockstal, Mieke; Sirtaine, Nicolas; Vermeulen, Peter; de Wind, Roland; Declercq, Sabine; Gevaert, Thomas; Haibe-Kans, Benjamin; H. Nelson, Brad; H. Watson, Peter; Leung, Sam; O. Nielsen, Torsten; Shi, Leming; Balslev, Eva; Thagaard, Jeppe; Almangush, Alhadi; Mäkitie, Antti; Joensuu, Heikki; Lundin, Johan; Drubay, Damien; Roblin, Elvire; André, Fabrice; Penault‐Llorca, Frédérique; Lemonnier, Jérôme; Adam, Julien; Lacroix‐Triki, Magali; Ternès, Nils; Radosevic‐Robin, Nina; Klaushen, Frederick; E. Weber, Karsten; Harbeck, Nadia; Gluz, Oleg; Wienert, Stephan; Cserni, Gábor; Vingiani, Andrea; Criscitiello, Carmen; Solinas, Cinzia; Curigliano, Giuseppe; Konishi, Eiichi; Suzuki, Eiji; Yoshikawa, Katsuhiro; Kawaguchi, Kosuke; Takada, Masahiro; Toi, Masakazu; Ishida, Mitsuaki; Shibata, Nobuhiro; Saji, Shigehira; Kogawa, Takahiro; Sakatani, Takashi; Okamoto, Takeru; Moriya, Takuya; R. Kataoka, Tatsuki; Shimoi, Tatsunori; Sugie, Tomohagu; Sugie, Tomoharu; Mukohara, Toru; Yazaki, Shu; Kikawa, Yuichiro; Kozuka, Yuji; Sayed, Shahin; Rahayu, Reena; Ramsaroop, Reena; Senkus, Elżbieta; Chmielik, Ewa; Cardoso, Fátima; Ribeiro, Joana; Junjie Chan, Jack; Dent, Rebecca; Martín, Miguel; Hagen, Carlos; Guerrero, Ángel; Rojo, Federico; Comerma, Laura; Nucíforo, Paolo; Vivo Serrano, Victor; Peg Cámaea, Vincente; G. Steenbruggen, Tessa; Ciompi, Francesco; Nederlof, Iris; Hudecek, Jan; van der Laak, Jeroen; van den Berg, José; Voorwerk, Leonie; van de Vijver, Mark; de Maaker, Michiel; C. Linn, Sabine; McKenzie, Hayley; Somaiah, Navita; Tutt, Andrew; Swanton, Charles; T. Hiley, Crispin; A. Moore, David; A. Hall, Jacqueline; Le Quesne, John; Abdul Jabbar, Khalid; Al Bakir, Maise; K. Hills, Robert; Irshad, Sheeba; Yuan, Yinyin; Li, Zaibo; C. Liu, Minetta; Klein, Jonathan; Fadare, Oluwole; M. Thompson, Alastair; J. Lazar, Alexander; M. Gown, Allen; Lo, Amy; C. Garrido Castro, Ana; Madabhushi, Anant; Moreira, André; L. Richardson, Andrea; H. Beck, Andrew; M. Bellizzi, Andrew; C. Wolff, Antonio; Harbhajanka, Aparna; Sharma, Ashish; Cimino‐Mathews, Ashley; Srinivasan, Ashok; Singh, Baljit; S. Chennubhotla, Chakra; Chauhan, Cynthia; Dillon, Deborah; Zardavas, Dimitrios; B. Johnson, Douglas; Thompson, Aubrey; Brogi, Edi; Reisenbichler, Emily; Huang, Erich; R. Hirsch, Fred; L. McArthur, Heather; Ziai, James; Brock, Jane; K. Kerner, Jennifer; Zha, Jiping; K. Lennerz, Jochen; M. Carter, Jodi; S. Reis‐Filho, Jorge; A. Sparano, Joseph; M. Balko, Justin; L. Pogue–Geile, Katherine; E. Steele, Keith; Blenman, Kim; H. Allison, Kimberly; Pusztai, Lajos; Cooper, Lee; M. Estrada, Valeria; Flowers, Margaret; E. Robson, Mark; C. Rebelatto, Marlon; G. Hanna, Matthew; P. Goetz, Matthew; Khojasteh, Mehrnoush; E. Sanders, Melinda; M. Regan, Meredith; J. Misialek, Michael; Amgad, Mohamed; Tung, Nadine; Singh, Rajendra; S.P. Huang, Richard; H. Pierce, Robert; A. Leon‐Ferre, Roberto; M. Swain, Sandra; Ely, Scott; Kim, Seong-Rim; Bedri, Shahinaz; Paik, Soonmyung; J. Schnitt, Stuart; d’Alfons, Timothy; Kurkure, Uday; Bossuyt, Veerle; Tong, Weida; Wang, Yihong; Henrique dos Anjos, Carlos; Gaire, Fabien; J. van Diest, Paul

doi:10.1038/s41523-021-00346-1

Public

The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Published in npj Breast Cancer • Dec 1, 2021

Authors:

Khalid El Bairi

Harry R. Haynes

Elizabeth F. Blackley

Abstract

The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potenti...

Subject

Oncology

Immunotherapy

Breast cancer

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