Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2

Galipeau, Yannick; Siragam, Vinayakumar; Laroche, Geneviève; Marion, Erika; Greig, Matthew; McGuinty, Michaeline; A. Booth, Ronald; Durocher, Yves; Čuperlović‐Culf, Miroslava; A. L. Bennett, Steffany; M. Crawley, Angela; M. Giguère, Patrick; Cooper, Curtis; Langlois, Marc‐André

doi:10.1016/j.ebiom.2021.103700

Public

Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2

Published in EBioMedicine • Nov 30, 2021

Authors:

Yannick Galipeau

Vinayakumar Siragam

Geneviève Laroche

Abstract

BACKGROUND: Antibodies raised against human seasonal coronaviruses (sCoVs), which are responsible for the common cold, are known to cross-react with SARS-CoV-2 antigens. This prompts questions about their protective role against SARS-CoV-2 infections and COVID-19 severity. However, the relationship ...

Subject

Neutralization

Antibody

Antigen

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