ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome.

T Baker, Alexander; J Boyd, Ryan; Sarkar, Daipayan; Teijeira-Crespo, Alicia; Kit Chan, Chun; Bates, Emily; Waraich, Kasim; Vant, John; Wilson, Eric; D Truong, Chloe; Lipka-Lloyd, Magdalena; Fromme, Petra; Vermaas, Josh; Williams, Dewight; Machiesky, LeeAnn; Heurich, Meike; M Nagalo, Bolni; Coughlan, Lynda; Umlauf, Scott; Chiu, Po-Lin; J Rizkallah, Pierre; S Cohen, Taylor; L Parker, Alan; Singharoy, Abhishek; J Borad, Mitesh

doi:10.1126/sciadv.abl8213

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ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome.

Published in Science advances • Dec 3, 2021

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Authors:

Alexander T Baker

,

Ryan J Boyd

,

Daipayan Sarkar

Abstract

Vaccines derived from chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26 (HAdV-D26), and human adenovirus type 5 (HAdV-C5) are critical in combatting the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic. As part of the largest vaccination campaign in history, ultrarare side ef...

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