RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis

Yue, Zhiying; Niu, Xin; Yuan, Zengjin; Qin, Qin; Jiang, Wenhao; He, Liang; Gao, Jingduo; Ding, Yi; Liu, Yanxi; Xu, Ziwei; Li, Zhenxi; Yang, Zhengfeng; Li, Rong; Xue, Xiwen; Gao, Yankun; Yue, Fei; H.-F. Zhang, Xiang; Hu, Guohong; Wang, Yi; Li, Yi; Chen, Geng; Siwko, Stefan; Gartland, Alison; Wang, Ning; Xiao, Jianru; Liu, Mingyao; Luo, Jian

doi:10.1172/jci144579

Public

RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis

Published in Journal of Clinical Investigation • Nov 30, 2021

Authors:

Zhiying Yue

Xin Niu

Zengjin Yuan

Abstract

Therapeutics targeting osteoclasts are commonly used treatments for bone metastasis; however, whether and how osteoclasts regulate premetastatic niche and bone tropism are largely unknown. In this study, we report that osteoclast precursors (OPs) can function as a premetastatic niche component that ...

Subject

DKK1

Bone metastasis

Wnt signaling pathway

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