Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation

Thiruvengadam, Muthu; Venkidasamy, Baskar; Subramanian, Umadevi; Samynathan, Ramkumar; Ali Shariati, Mohammad; Ребезов, Максим; Girish, Shabari; Thangavel, Sivakumar; Raj Dhanapal, Anand; A. Fedoseeva, N.; Lee, Joohyun; Chung, Ill‐Min

doi:10.3390/antiox10121859

Public

Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2/ARE Signaling Pathway and Epigenetic Regulation

Published in Antioxidants • Nov 23, 2021

Authors:

Muthu Thiruvengadam

Baskar Venkidasamy

Umadevi Subramanian

Abstract

Oxidative stress is a pathological condition occurring due to an imbalance between the oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 (NRF2), encoded by the gene NFE2L2, is the master regulator of phase II antioxidant enzymes that protect against oxidative s...

Subject

Oxidative stress

Epigenetics

Signal transduction

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