Vasoconstrictor antagonism improves functional and structural vascular alterations and liver damage in rats with early NAFLD

van der Graaff, Denise; Chotkoe, Shivani; Y. De Winter, Benedicte; De Man, Joris; Casteleyn, Christophe; Timmermans, Jean‐Pierre; Pintelon, Isabel; Vonghia, Luisa; J. Kwanten, Wilhelmus; Francque, Sven

doi:10.1016/j.jhepr.2021.100412

Public

Vasoconstrictor antagonism improves functional and structural vascular alterations and liver damage in rats with early NAFLD

Published in JHEP Reports • Nov 24, 2021

Authors:

Denise van der Graaff

Shivani Chotkoe

Benedicte Y. De Winter

Abstract

BACKGROUND & AIMS: Intrahepatic vascular resistance is increased in early non-alcoholic fatty liver disease (NAFLD), potentially leading to tissue hypoxia and triggering disease progression. Hepatic vascular hyperreactivity to vasoconstrictors has been identified as an underlying mechanism. This stu...

Subject

Antagonism

Medicine

Liver damage

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