Interleukin-1 Is Overexpressed in Injured Muscles Following Spinal Cord Injury and Promotes Neurogenic Heterotopic Ossification

Tseng, Hsu‐Wen; Kulina, Irina; Girard, Dorothée; Gueguen, Jules; Vaquette, Cedryck; Salga, Marjorie; Fleming, Whitney; Jose, Beulah; Millard, Susan; R. Pettit, Allison; Schroder, Kate; Thomas, Gethin; Wheeler, Lawrie; Genêt, François; Banzet, Sébastien; A. Alexander, Kylie; Lévesque, Jean-Pierre

doi:10.1002/jbmr.4482

Public

Interleukin-1 Is Overexpressed in Injured Muscles Following Spinal Cord Injury and Promotes Neurogenic Heterotopic Ossification

Published in Journal of Bone and Mineral Research • Dec 1, 2020

Authors:

Hsu‐Wen Tseng

Irina Kulina

Dorothée Girard

Abstract

ABSTRACT Neurogenic heterotopic ossifications (NHOs) form in periarticular muscles after severe spinal cord (SCI) and traumatic brain injuries. The pathogenesis of NHO is poorly understood with no effective preventive treatment. The only curative treatment remains surgical resection of pathological ...

Subject

Inflammation

Medicine

Heterotopic ossification

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