Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

S. Storm, Catherine; A. Kia, Demis; Mohammad Almramhi, Mona; Bandrés‐Ciga, Sara; Finan, Chris; J. Noyce, Alastair; Kaiyrzhanov, Rauan; Middlehurst, Ben; Tan, Manuela; Houlden, Henry; R. Morris, Huw; Plun‐Favreau, Hélène; Holmans, Peter; Hardy, John; Trabzuni, Daniah; P. Quinn, John; J. Bubb, Vivien; Y. Mok, Kin; J. Kinghorn, Kerri; A. Lewis, Patrick; R. Schreglmann, Sebastian; C. Lovering, Ruth; R’Bibo, Lea; Manzoni, Claudia; Rizig, Mie; Ryten, Mina; Guelfi, Sebastian; Escott‐Price, Valentina; Chelban, Viorica; Foltynie, Thomas; Williams, Nigel; Morrison, Karen; E Clarke, Carl; Harvey, Kirsten; M. Jacobs, Benjamin; Brice, Alexis; Danjou, Fabrice; Lesage, Suzanne; Corvol, Jean‐Christophe; Martínez, María; Schulte, Claudia; Brockmann, Kathrin; Simón‐Sánchez, Javier; Heutink, Peter; Rizzu, Patrizia; Sharma, Manu; Gasser, Thomas; A. Schneider, Susanne; Cookson, Mark; Blauwendraat, Cornelis; W. Craig, David; J. Billingsley, Kimberley; B. Makarious, Mary; P. Narendra, Derek; Faghri, Faraz; Raphael Gibbs, J.; Hernández, Dena; Van Keuren‐Jensen, Kendall; Shulman, Joshua; Iwaki, Hirotaka; L. Leonard, Hampton; A. Nalls, Mike; Robak, Laurie; Brás, José; Guerreiro, Rita; Lubbe, Steven; Troycoco, Timothy; Finkbeiner, Steven; E. Mencacci, Niccolò; Lungu, Codrin; Singleton, Andrew; W. Scholz, Sonja; Reed, Xylena; J. Uitti, Ryan; A. Ross, Owen; P. Grenn, Francis; Moore, Anni; N. Alcalay, Roy; K. Wszołek, Zbigniew; Gan‐Or, Ziv; A. Rouleau, Guy; Krohn, Lynne; Mufti, Kheireddin; J. van Hilten, Jacobus; Marinus, Johan; D. Adarmes-Gómez, Astrid; Aguilar, Miquel; Álvarez, Ignacio; Álvarez, Victoria; Javier Barrero, Francisco; Alberto Bergareche Yarza, Jesús; Bernal‐Bernal, Inmaculada; Blázquez Estrada, Marta; Bonilla‐Toribio, Marta; A. Botía, Juan; Teresa Boungiorno, María; Buiza‐Rueda, Dolores; Cámara, Ana; Carrillo, Fátima; Carrión‐Claro, Mario; Cerdan, Debora; Clarimón, Jordi; Compta, Yaroslau; Díez-Fairén, Mónica; Dols‐Icardo, Oriol; Duarte, Jacinto; Durán, Raquel; Escamilla‐Sevilla, Francisco; Ezquerra, Mario; Feliz, Cici; Fernández, Manel; Fernández‐Santiago, Rubén; García, Ciara; Ruiz, Pedro; Gómez‐Garre, Pilar; José Gómez Heredia, María; González Aramburu, Isabel; Gorostidi Pagola, Ana; Hoenicka, Janet; Infante, Jon; Jesús, Silvia; Jiménez‐Escrig, Adriano; Kulisevsky, Jaime; A. Labrador‐Espinosa, Miguel; Luis López-Sendón, José; López de Munaín Arregui, Adolfo; Macías, Daniel; Martínez‐Torres, Irene; Marín‐Lahoz, Juan; José Martı́, Marı́a; Carlos Martínez‐Castrillo, Juan; Méndez‐del‐Barrio, Carlota; Menéndez‐González, Manuel; Mata, Marina; Mínguez‐Castellanos, Adolfo; Mir, Pablo; Mondragón Rezola, Elisabet; Muñoz, Esteban; Pagonabarraga, Javier; Pástor, Pau; Pérez Errazquin, Francisco; Teresa Periñán, María; Ruiz‐Martínez, Javier; Ruz, Clara; Rodríguez, A; Sierra, María; Suárez-Sanmartín, Esther; Tabernero, César; Pablo Tartari, Juan; Tejera‐Parrado, Cristina; Tolosa, Eduard; Valldeoriola, Francesc; Vargas‐González, Laura; Vela, Lydia; Vives, Francisco; Zimprich, Alexander; Pihlstrøm, Lasse; Toft, Mathias; Taba, Pille; Kõks, Sulev; Hassin‐Baer, Sharon; Majamaa, Kari; Siitonen, Ari; Tienari, Pentti; Okubadejo, Njideka; O. Ojo, Oluwadamilola; Shashkin, Chingiz; Zharkinbekova, Nazira; Akhmetzhanov, Vadim; Kaishybayeva, Gulnaz; Karimova, Altynay; Т.Н., Хайбуллин; Lynch, Timothy; D. Hingorani, Aroon; Wood, Nicholas

doi:10.1038/s41467-021-26280-1

Public

Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

Published in Nature Communications • Dec 20, 2021

Authors:

Catherine S. Storm

Demis A. Kia

Mona Mohammad Almramhi

Abstract

Parkinson's disease is a neurodegenerative movement disorder that currently has no disease-modifying treatment, partly owing to inefficiencies in drug target identification and validation. We use Mendelian randomization to investigate over 3,000 genes that encode druggable proteins and predict their...

Subject

Mendelian randomization

Druggability

Disease

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