Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment

Kuett, Laura; Catena, Raúl; Özcan, Alaz; Plüss, Alex; Raza Ali, H.; Al Sa’d, M.; Alon, Shahar; Aparício, Samuel; Battistoni, Giorgia; Balasubramanian, Shankar; Becker, Robert; Bodenmiller, Bernd; Bodenmiller, B.; S. Boyden, E.; Bressan, Dario; Bruna, Alejandra; Burger, Marcel; Caldas, Carlos; Callari, Maurizio; G. Cannell, Ian; Casbolt, Helen; Chornay, N.; Cui, Y.; Dariush, A.; Dinh, K.; Emenari, A.; Eyal-Lubling, Y.; Linyue Fan, Joy; Fatemi, Ali; A. Fisher, Edward; A. González-Solares, E.; Gónzalez-Fernández, C.; Goodwin, Daniel; Greenwood, Wendy; Grimaldi, Francesco; J. Hannon, Gregory; Harris, Shelley; Jauset, Cristina; A. Joyce, Johanna; D. Karagiannis, Emmanouil; Kovačević, Tatjana; Kuett, L.; Kunes, Russell; Yoldaş, A.; Lai, D.; Laks, E.; Lee, M.; Lee, M.; Lerda, Giulia; Li, Y.; McPherson, Andrew; L. Millar, Neal; M. Mulvey, Claire; Nugent, I.; H. O’Flanagan, Ciara; Pàez‐Ribes, Marta; Pearsall, I.; Qosaj, Fatime; Roth, Andrew; M. Rueda, Oscar; Ruiz, Tamara; Sawicka, Kirsty; A. Sepúlveda, Leonardo; P. Shah, S.; Shea, A.; Sinha, Anubhav; L. Smith, Adrian; Tavaré, S.; Tietscher, Sandra; Vázquez-Garćıa, Ignacio; Vogl, Siegfried; A. Walton, N.; T. Wassie, Asmamaw; S. Watson, Spencer; Weselak, Joanna; Wild, Sonja; T. Williams, Elyse; Windhager, Jonas; Xia, C.; Zheng, P.; Zhuang, X.; Schraml, Peter; Moch, Holger; de Souza, Natalie; Bodenmiller, Bernd; Bodenmiller, Bernd

doi:10.1038/s43018-021-00301-w

Public

Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment

Published in Nature Cancer • Dec 24, 2021

Authors:

Laura Kuett

Raúl Catena

Alaz Özcan

Abstract

A holistic understanding of tissue and organ structure and function requires the detection of molecular constituents in their original three-dimensional (3D) context. Imaging mass cytometry (IMC) enables simultaneous detection of up to 40 antigens and transcripts using metal-tagged antibodies but ha...

Subject

Mass cytometry

Context (archaeology)

Computational biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!