Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19

Bi, Xiaojie; Liu, Wei; Ding, Xuan; Liang, Shuang; Zheng, Yufen; Zhu, Xiaoli; Quan, Sheng; Yi, Xiao; Xiang, Nan; Du, Juping; Lyu, Haiyan; Yu, Die; Zhang, Chao; Xu, Luang; Ge, Weigang; Zhan, Xinke; He, Jiale; Jian Xiong, Zi; Zhang, Shun; Li, Yanchang; Xu, Ping; Zhu, Guangjun; Wang, Donglian; Zhu, Hongguo; Chen, Shiyong; Li, Jun; Zhao, Haihong; Zhu, Yi; Liu, Huafen; Xu, Jiaqin; Shen, Bo; Guo, Tiannan

doi:10.1016/j.celrep.2021.110271

Public

Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19

Published in Cell Reports • Dec 28, 2021

Authors:

Xiaojie Bi

Wei Liu

Xuan Ding

Abstract

The utility of the urinary proteome in infectious diseases remains unclear. Here, we analyzed the proteome and metabolome of urine and serum samples from patients with COVID-19 and healthy controls. Our data show that urinary proteins effectively classify COVID-19 by severity. We detect 197 cytokine...

Subject

Proteome

Urinary system

Immune system

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