Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels

Bamlanivimab Study Group*, ACTIV-3/TICO; D. Lundgren, Jens; Grund, Birgit; E. Barkauskas, Christina; L. Holland, Thomas; L. Gottlieb, Robert; Sandkovsky, Uriel; M. Brown, Samuel; U. Knowlton, Kirk; H. Self, Wesley; Clark Files, D.; K. Jain, Mamta; Benfield, Thomas; E. Bowdish, Michael; G. Leshnower, Bradley; V. Baker, Jason; Jensen, Jens-Ulrik; M. Gardner, Edward; A. Ginde, Adit; S. Harris, Estelle; S. Johansen, Isik; Markowitz, Norman; A. Matthay, Michael; Østergaard, Lars; C. Chang, Christina; L. Goodman, Anna; Chang, Weizhong; L. Dewar, Robin; P. Gerry, Norman; S. Higgs, Elizabeth; Highbarger, Helene; D. Murray, Daniel; A. Murray, Thomas; Natarajan, Ven; Paredes, Roger; K.B. Parmar, Mahesh; N. Phillips, Andrew; Reilly, Cavan; W. Rupert, Adam; Sharma, Shweta; Shaw-Saliba, Kathryn; T. Sherman, Brad; Teitelbaum, Marc; Wentworth, Deborah; Cao, Huyen; Klekotka, Paul; G. Babiker, Abdel; J. Davey, Victoria; C. Gelijns, Annetine; L. Kan, Virginia; N. Polizzotto, Mark; Taylor Thompson, B.; Clifford Lane, H.; D. Neaton, James; Clifford Lane, H.; Tierney, John; S. Higgs, Elizabeth; Barrett, Kevin; R. Herpin, Betsey; C. Smolskis, Mary; E. Vogel, Susan; A. McNay, Laura; Cahill, Kelly; Crew, Page; Kirchoff, Matthew; Sardana, Ratna; Segal Raim, Sharon; Shaw-Saliba, Kathryn; J. Adam, Stacey; Read, Sarah; Hughes, Eric; H. Harrigan, Rachel; Baseler, R.; J. Teitelbaum, Marc; M. Simpson, Shelly; J. Buehn, Molly; Vallée, David; Eccard-Koons, Vanessa; Kopka, Stacey; M. Engel, Theresa; Osborne, Cynthia; Giambarresi MacDonald, Leah; M. Harmon, Liam; M. Shelley, Denise; Ha Kim, Mi; Beeler-Knights, Joy; Yeon, Lindsey; L. Dewar, Robin; Natarajan, Ven; Chang, Weizhong; T. Sherman, Brad; W. Rupert, Adam; Highbarger, Helene; Baseler, Michael; Lallemand, Perrine; Rehman, Tauseef; Lynam, Danielle; Mendez, Gregg; Imamichi, Tom; Laverdure, Sylvain; Paudel, Sharada; Cook, Kyndal; Brown, Shawn; Khan, Ayub; Hazen, Allison; Badralmaa, Yunden; D. Neaton, James; Amos, Laura; Carter, Anita; Collins, Gary; Davis, Bionca; Denning, Eileen; DuChene, Alain; Engen, Nicole; Grandits, Greg; Grund, Birgit; Harrison, Merrie; Hurlbut, Nancy; Koopmeiners, Joseph; Larson, Gregg; Meger, Sue; Sharma Mistry, Shweta; Murray, Thomas; Nelson, Ray; Quan, Kien; Fun Quan, Siu; Reilly, Cavan; Thompson, Greg; Vock, David; Wentworth, Deborah; C. Gelijns, Annetine; J. Moskowitz, Alan; Bagiella, Emilia; Moquete, Ellen; O’Sullivan, Karen; Accardi, Evan; Kinzel, Emily; Bedoya, Gabriela; Gupta, Lopa; R. Overbey, Jessica; L. Padillia, Maria; Santos, Milerva; A. Miller, Marissa; C. Taddei-Peters, Wendy; Fenton, Kathleen; K. Smith, Peter; E. Barkauskas, Christina; M. Vekstein, Andrew; R. Ko, Emily; Der, Tatyana; Franzone, John; Ivey, Noel; L. Holland, Thomas; Lane, Kathleen; Bouffler, Andrew; M. McGowan, Lauren; Stallings, Ben; Stout, Jennifer; Franz, Whitney; McLendon-Arvik, Beth; A. Hollister, Beth; M. Giangiacomo, Dana; Sandkovsky, Uriel; L. Gottlieb, Robert; Mack, Michael; Berhe, Mezgebe; Haley, Clinton; Dishner, Emma; Bettacchi, Christopher; Golden, Kevin; Duhaime, Erin; Spak, Cedric; Burris, Sarah; Jones, Felecia; Villa, Samantha; Wang, Samantha; Robert, Raven; Coleman, Tanquinisha; Clariday, Laura; Baker, Rebecca; Hurutado, Mariana; Iram, Nazia; Fresnedo, Michelle; Davis, Allyson; Leonard, Kiara; Ramierez, Noelia; Thammavong, Jon; Duque, Krizia; Turner, Emma; Killian, Aaron; Palacious, Adriana; Solis, Edilia; Jerrow, Janet; Watts, Matthew; Whitacre, Heather; Cothran, Elizabeth; E. Bowdish, Michael; Borok, Zea; Wald-Dickler, Noah; Hutcheon, Douglass; Towfighi, Amytis; Lee, May; R. Lewis, Meghan; Spellberg, Brad; Sher, Linda; Sharma, Aniket; P. Olds, Anna; Justino, Chris; Lozano, Edward; Romero, Chris; Leong, Janet; Rodina, Valentina; Quesada, Christine; Hamilton, Luke; Escobar, Jose; Leshnower, Brad; Bender, William; Sharifpour, Milad; Miller, Jeffrey; T. Baio, Kim; K. McBride, Mary; Fielding, Michele; Mathewson, Sonya; Porte, Kristina; Maton, Missy; Ponder, Chari; Haley, Elizabeth; Spainhour, Christine; Rogers, Susan; Tyler, Derrick; M. Sturek, Jeffrey; Barros, Andrew; B. Enfield, Kyle; J. Green, China; M. Simon, Rachel; Thornton, Kara; E. Parrino, Patrick; Spindel, Stephen; Bansal, Aditya; Baumgarten, Katherine; Hand, Jonathan; Vonderhaar, Derek; Nossaman, Bobby; Laudun, Sylvia; Ames, DeAnna; Isaac, Geralyn; Dinh, Huan; Zheng, Yiling; McDaniel, Hunter; Crovetto, Nicolle; Richardson, Abby; Badhwar, Vinay; Awori Hayanga, J.; Sharma, Sunil; Peppers, Brian; McCarthy, Paul; Krupica, Troy; Sarwari, Arif; Reece, Rebecca; Fornaresio, Lisa; Glaze, Chad; Evans, Raquel; Di, Fang; Carlson, Shawn; Aucremanne, Tanja; Tennant, Connie; Giblin Sutton, Lisa; Buterbaugh, Sabrina; Williams, Roger; Bunner, Robin; J. Madathil, Ronson; Rabin, Joseph; Levine, Andrea; Saharia, Kapil; Tabatabai, Ali; Lau, Christine; S. Gammie, James; Peguero, Maya-Loren; McKernan, Kimberly; Audette, Matthew; Fleischmann, Emily; Akbari, Kreshta; Lee, Myounghee; Chi, Andrew; Salehi, Hanna; Pariser, Alan; Tran Nyguyen, Phuong; Moore, Jessica; Gee, Adrienne; Vincent, Shelika; A. Zuckerman, Richard; Iribarne, Alexander; Metzler, Sara; Shipman, Samantha; Caccia, Taylor; Johnson, Haley; Newton, Crystallee; Parr, Doug; Rodriguez, Vicente; Bokhart, Gordon; M. Eichman, Sharon; Taylor Thompson, B.; North, Crystal; Oldmixon, Cathryn; Ringwood, Nancy; Fitzgerald, Laura; Muzikansky, Ariela; Morse, Richard; G. Brower, Roy; A. Reineck, Lora; R. Aggarwal, Neil; Hou, Peter; S. Steingrub, Jay; A. Tidswell, Mark; Kozikowski, Lori-Ann; Kardos, Cynthia; De Souza, Leslie; Talmor, Daniel; Shapiro, Nathan; E. Jones, Alan; Galbraith, James; Nandi, Utsav; Peacock, Rebekah; R. Filbin, Michael; Hibbert, Kathryn; Alden Parry, Blair; D. Margolin, Justin; Brait, Kelsey; Hendey, Gregory; A. Matthay, Michael; N. Kangelaris, Kirsten; J. Yee, Kimberly; E. Jauregui, Alejandra; Zhuo, Hanjing; Almasri, Eyad; R. Hughes, Alyssa; L. Garcia, Rebekah; A. Hubel, Kinsley; J. Rogers, Angela; G. Wilson, Jennifer; Vojnik, Rosemary; Roque, Jonasel; Wang, Henry; M. Huebinger, Ryan; Patel, Bela; Vidales, Elizabeth; A. Ginde, Adit; Baduashvili, Amiran; Chauhan, Lakshmi; J. Douin, David; L. Finck, Lani; Higgins, Carrie; Howell, Michelle; McKeehan, Jeffrey; Moss, Marc; H. Finigan, James; Janssen, William; Stubenrauch, Peter; Griesmer, Christine; C. Hyzy, Robert; K. Park, Pauline; Nelson, Kristine; McDonough, Kelli; I. McSparron, Jake; N. Co, Ivan; R. Wang, Bonnie; Jia, Shijing; Sullins, Barbara; Hanna, Sinan; Olbrich, Norman; D. Richardson, Lynne; N. Gong, Michelle; Nair, Rahul; M. Mosier, Jarrod; Hypes, Cameron; Salvagio Campbell, Elizabeth; Bixby, Billie; Bime, Christian; Parthasarathy, Sairam; Duncan Hite, R.; E. Terndrup, Thomas; P. Wiedemann, Herbert; Duggal, Abhijit; Dugar, Siddharth; Sahoo, Debasis; Ashok, Kiran; H. King, Alexander; Mehkri, Omar; J. Johnson, Nicholas; H. Robinson, Bryce; J. Gundel, Stephanie; C. Katsandres, Sarah; L. Hough, Catherine; Khan, Akram; F. Krol, Olivia; Kinjal, Mistry; K. Jouzestani, Milad; Chen, Peter; S. Torbati, Sam; Matusov, Yuri; Choe, June; A. Hindoyan, Niree; E. Jackman, Susan; Bayoumi, Emad; Wynter, Timothy; Caudill, Antonina; Pascual, Ethan; J. Clapham, Gregg; Herrera, Lisa; Miller, Chadwick; Clark Files, D.; W. Gibbs, Keven; S. Flores, Lori; E. LaRose, Mary; D. Landreth, Leigha; E. Morris, Peter; L. Sturgill, Jamie; P. Cassity, Evan; Dhar, Sanjay; A. Montgomery-Yates, Ashley; N. Pasha, Sara; P. Mayer, Kirby; de Wit, Marjolein; Mason, Jessica; M. Brown, Samuel; Bledsoe, Joseph; U. Knowlton, Kirk; Lanspa, Michael; Leither, Lindsey; Pelton, Ithan; P. Armbruster, Brent; Montgomery, Quinn; Applegate, Darrin; Kumar, Naresh; Fergus, Melissa; Brown, Katie; Merrill, Mardee; Serezlic, Erna; Palmer, Ghazal; Webb, Brandon; T. Aston, Valerie; S. Harris, Estelle; A. Middleton, Elizabeth; A.G. Barrios, Macy; Greer, Jorden; D. Schmidt, Amber; K. Webb, Melissa; Paine, Robert; J. Callahan, Sean; H. Self, Wesley; W. Rice, Todd; D. Casey, Jonathan; Johnson, Jakea; Gray, Christopher; Hays, Margaret; Roth, Megan; L. Kan, Virginia; Sánchez, Adriana; Popielski, Laura; Rivasplata, Heather; Turner, Melissa; J. Vjecha, Michael; Weintrob, Amy; K. Jain, Mamta; Petersen, Tianna; Sanchez Lucas, Claudia; Avery, Alexis; Hansen, Laura; DellaValle, Natalie; Moss, Khanh-Hau; V. Baker, Jason; Klaphake, Jonathan; Mackedanz, Shari; Goldsmith, Rachael; Jibrell, Hodan; Markowitz, Norman; Pastor, Erika; Ramesh, Mayur; Brar, Indira; Rivers, Emanuel; Gardner, Edward; Scott, James; Wyles, David; Douglas, Ivor; Haukoos, Jason; Cohen, Mitch; Kamis, Kevin; Robinson, Caitlin; Kumar, Princy; Menna, Maximilian; J. Davey, Victoria; Biswas, Kousick; Harrington, Cristin; W. Trautner, Barbara; Pandit, Lavannya; Dillon, Laura; Hines-Munson, Casey; Johnson, Biju; Joseph, Marilyn; Van, John; Wang, Yiqun; Lichtenberger, Paola; Baracco, Gio; Ramos, Carol; Bjork, Lauren; Sueiro, Melyssa; Tien, Phyllis; Freasier, Heather; Buck, Theresa; Nekach, Hafida; D. Lundgren, Jens; Raben, Dorthe; D. Murray, Daniel; Peters, Lars; Aagaard, Bitten; B. Nielsen, Charlotte; Krapp, Katharina; Rosdahl Nykjær, Bente; Lisa Kanne, Katja; Louise Grevsen, Anne; Maria Joensen, Zillah; Bruun, Tina; Benfield, Thomas; Lundetoft Clausen, Clara; Hovmand, Nichlas; Bastrup Israelsen, Simone; Krohn-Dehli, Louise; Leding, Cæcilie; Pedersen, Dorthe; Brorup Pedersen, Karen; Thorlacius-Ussing, Louise; Tinggaard, Michaela; Tingsgård, Sandra; Villadsen, Signe; Stæhr Jensen, Jens-Ulrik; S. Høgsberg, Dorthe; P. Rønn, Christian; Rastoder, Ema; Søborg, Christian; Bergsøe, Christina; M.S. Hissabu, Nuria; C. Arp, Bodil; Østergaard, Lars; Breinholt Stærke, Nina; Arnholdt Pedersen, Andreas; K. Holden, Inge; Helleberg, Marie; Gerstoft, Jan; O. Jensen, Tomas; Lindegaard, Birgitte; Thorup Røge, Birgit; Nielsen, Henrik; Chamorro, Anna; Figuerola, Ariadna; Exposito, Maria; Paredes, Roger; Mateu, Lourdes; Martínez, Ana; Siles, Adrian; Fernández-Cruz, Eduardo; Carbone, Javier; López, Paco; Muñoz, José; Camprubí, Daniel; Legarda, Almudena; R. Arribas, Jose; Borobia, Alberto; Mora-Rillo, Marta; García García, Irene; Estrada, Vicente; Cabello, Noemi; Jose Nuñez, Maria; P. Horcajada, Juan; Sendra, Elena; Gómez-Junyent, Joan; Polizzotto, Mark; Cabrera, Gesalit; Carey, Catherine; C. Chang, Christina; Hough, Sally; Virachit, Sophie; Zhong, Amy; E. Young, Barnaby; Ying Chia, Po; Hong Lee, Tau; J. Lin, Ray; Lye, David; Ong, Sean; Hon Puah, Ser; Wen Yeo, Tsin; Hui Diong, Shiau; Ongko, Juwinda; G. Babiker, Abdel; L. Pett, Sarah; Hudson, Fleur; K.B. Parmar, Mahesh; L. Goodman, Anna; Badrock, Jonathan; Gregory, Adam; Touloumi, Giota; Gioukari, Vicky; Lutaakome, Joseph; M. Kityo, Cissy; Kiweewa, Francis; Klekotka, Paul; Price, Karen; Nirula, Ajay; Osinusi, Anu; Cao, Huyen; Kubernac, Amanda; Patel, Bhakti; Smith, Kenneth; Kubernac, Robert; P. Gerry, Norman; L. Hoover, Marie; Brown, Craig; DuChateau, Nadine; Flosi, Adam; Johnson, Les; Treagus, Amy; Wenner, Christine

doi:10.7326/m21-3507

Public

Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels

Published in Annals of Internal Medicine • Dec 20, 2021

Authors:

ACTIV-3/TICO Bamlanivimab Study Group*

Jens D. Lundgren

Birgit Grund

Abstract

Background: In a randomized, placebo-controlled, clinical trial, bamlanivimab, a SARS-CoV-2–neutralizing monoclonal antibody, given in combination with remdesivir, did not improve outcomes among hospitalized patients with COVID-19 based on an early futility assessment. Objective: To evaluate the a p...

Subject

Medicine

Immunology

Monoclonal antibody

Research Assistant

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