MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model

Wen, Qianwen; Wang, Yunfeng; Pan, Qi; Tian, Ruimin; Zhang, Dunke; Qin, Guangcheng; Zhou, Jiying; Chen, Lixue

doi:10.1186/s12974-021-02342-5

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MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model

Shared by NobleBlocks on Dec 10, 2021 • 12:00 AM UTC

Authors:

Qianwen Wen

Yunfeng Wang

Qi Pan

Abstract

Abstract Background Previous studies have confirmed that the microglial activation and subsequent inflammatory responses in the trigeminal nucleus caudalis (TNC) are involved in the central sensitization of chronic migraine (CM). MicroRNA-155-5p has been shown to modulate the polarization of microgl...

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