Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

C. Dowell, Alexander; S. Butler, Megan; Jinks, Elizabeth; Tut, Gokhan; Lancaster, Tara; Sylla, Panagiota; Begum, Jusnara; Bruton, Rachel; Pearce, Hayden; Verma, Kriti; Logan, Nicola; Tyson, Grace; Spalkova, Eliska; Margielewska-Davies, Sandra; S. Taylor, Graham; Syrimi, Eleni; Baawuah, Frances; Beckmann, Joanne; O. Okike, Ifeanyichukwu; Ahmad, Shazaad; Garstang, Joanna; J. Brent, Andrew; Brent, Bernadette; Ireland, Georgina; Aiano, Felicity; Amin-Chowdhury, Zahin; Jones, Samuel; Borrow, Ray; Linley, Ezra; Wright, John; Azad, Rafaq; Waiblinger, Dagmar; Davis, Chris; C. Thomson, Emma; Palmarini, Massimo; J. Willett, Brian; S. Barclay, Wendy; Poh, John; Amirthalingam, Gayatri; E. Brown, Kevin; E. Ramsay, Mary; Zuo, Jianmin; Moss, Paul; Ladhani, Shamez

doi:10.1038/s41590-021-01089-8

Public

Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

Shared by NobleBlocks on Dec 22, 2021 • 12:00 AM UTC

Authors:

Alexander C. Dowell

Megan S. Butler

Elizabeth Jinks

Abstract

Abstract SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome is unclear. Here we compare antibody and cellular immunity in children (aged 3–11 years) and adults. Antibody responses against spike protein were high in children and seroconversion b...

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