Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

C. Dowell, Alexander; Butler, Megan; Jinks, Elizabeth; Tut, Gokhan; Lancaster, Tara; Sylla, Panagiota; Begum, Jusnara; Bruton, Rachel; Pearce, Hayden; Verma, Kriti; Logan, Nicola; Tyson, Grace; Spalkova, Eliska; Margielewska‐Davies, Sandra; S. Taylor, Graham; Syrimi, Eleni; Baawuah, Frances; Beckmann, Joanne; Okike, Ifeanyichukwu; Ahmad, Shazaad; Garstang, Joanna; Brent, Andrew; Brent, Bernadette; Ireland, Georgina; Aiano, Felicity; Amin‐Chowdhury, Zahin; E. I. Jones, Samuel; Borrow, Ray; Linley, Ezra; Wright, John; Azad, Rafaq; Waiblinger, Dagmar; Davis, Christopher; C. Thomson, Emma; Palmarini, Massimo; J. Willett, Brian; Barclay, William; Poh, John; Amirthalingam, Gayatri; Brown, Kevin; Ramsay, Mary; Zuo, Jianmin; Moss, Paul; Ladhani, Shamez

doi:10.1038/s41590-021-01089-8

Public

Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

Published in Nature Immunology • Dec 22, 2021

Authors:

Alexander C. Dowell

Megan Butler

Elizabeth Jinks

Abstract

SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for this outcome is unclear. Here we compare antibody and cellular immunity in children (aged 3-11 years) and adults. Antibody responses against spike protein were high in children and seroconversion boosted re...

Subject

Seroconversion

Immunology

Antibody

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