EIF4A3-Induced circARHGAP29 Promotes Aerobic Glycolysis in Docetaxel-Resistant Prostate Cancer through IGF2BP2/c-Myc/LDHA Signaling

Jiang, Xingkang; Guo, Shanqi; Wang, Shuo; Zhang, Yangyi; Chen, Haojie; Wang, Yong; Liu, Ranlu; Niu, Yuanjie; Xu, Yong

doi:10.1158/0008-5472.can-21-2988

Public

EIF4A3-Induced circARHGAP29 Promotes Aerobic Glycolysis in Docetaxel-Resistant Prostate Cancer through IGF2BP2/c-Myc/LDHA Signaling

Published in Cancer Research • Dec 29, 2021

Authors:

Xingkang Jiang

Shanqi Guo

Shuo Wang

Abstract

Docetaxel-based chemotherapy is a standard-of-care treatment for metastatic prostate cancer, and chemoresistance remains a major challenge in clinical practice. Recent studies have demonstrated that circular RNAs (circRNA) play critical roles in the development and progression of prostate cancer. Ho...

Subject

Prostate cancer

Docetaxel

Anaerobic glycolysis

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