A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression

Peng, Yin; Xu, Yidan; Zhang, Xiaojing; Deng, Shiqi; Yuan, Yuan; Luo, Xiaonuan; Tofazzal Hossain, Md.; Zhu, Xiaohui; Du, Kaining; Hu, Fan; Chen, Yang; Chang, Shanshan; Feng, Xianling; Fan, Xinmin; Ashktorab, Hassan; T. Smoot, Duane; J. Meltzer, Stephen; Hou, Gangqiang; Wei, Yanjie; Li, Song; Qin, Ying�; Jin, Zhe

doi:10.1186/s12943-021-01457-w

Public

A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression

Published in Molecular Cancer • Dec 4, 2021

Authors:

Yin Peng

Yidan Xu

Xiaojing Zhang

Abstract

BACKGROUND: Circular RNA (circRNA), a subclass of non-coding RNA, plays a critical role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a microRNA sponge or a scaffold to interact with protein complexes; however, its full range of functions remains elusive. Recentl...

Subject

Wnt signaling pathway

Biology

Chromatin immunoprecipitation

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