Interleukin‐1β–Activated Microvascular Endothelial Cells Promote DC‐SIGN–Positive Alternatively Activated Macrophages as a Mechanism of Skin Fibrosis in Systemic Sclerosis

Laurent, Paôline; Lapoirie, J.; Leleu, Damien; Levionnois, Émeline; Grenier, Cyrielle; Jurado-Mestre, B.; Lazaro, Estibaliz; Duffau, P.; Richez, Christophe; Sénéschal, Julien; Pellegrin, Jean‐Luc; Constans, J.; Schaeverbeke, Thierry; Douchet, Isabelle; Duluc, Dorothée; Pradeu, Thomas; Chizzolini, Carlo; Blanco, Patrick; Truchetet, Marie‐Elise; Contin‐Bordes, Cécile

doi:10.1002/art.42061

Public

Interleukin‐1β–Activated Microvascular Endothelial Cells Promote DC‐SIGN–Positive Alternatively Activated Macrophages as a Mechanism of Skin Fibrosis in Systemic Sclerosis

Published in Arthritis & Rheumatology • Dec 28, 2021

Authors:

Paôline Laurent

J. Lapoirie

Damien Leleu

Abstract

OBJECTIVE: To characterize the role of interleukin-1β (IL-1β) and microvascular endothelial cells (MVECs) in the generation of alternatively activated macrophages in the skin, and to explore their role in the development of skin fibrosis in patients with systemic sclerosis (SSc; scleroderma). METHOD...

Subject

Fibrosis

Immunofluorescence

Macrophage

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