Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

Dion-Albert, Laurence; Cadoret, Alice; Doney, Ellen; Neutzling Kaufmann, Fernanda; A. Dudek, Katarzyna; Daigle, Beatrice; F. Parise, Lyonna; Cathomas, Flurin; Samba, Nalia; Hudson, Natalie; Lebel, Manon; Aardema, Frederic; Ait Bentaleb, Lahcen; Beauchamp, Janique; Bendahmane, Hicham; Benoit, Elise; Bergeron, Lise; Bertone, Armando; Bertrand, Natalie; Berube, Felix-Antoine; Blanchet, Pierre; Boissonneault, Janick; J. Bolduc, Christine; Bonin, Jean-Pierre; Borgeat, Francois; Boyer, Richard; Breault, Chantale; Breton, Jean-Jacques; Briand, Catherine; Brodeur, Jacques; Brule, Krystele; Brunet, Lyne; Carriere, Sylvie; Chartrand, Carine; Chenard-Soucy, Rosemarie; Chevrette, Tommy; Cloutier, Emmanuelle; Cloutier, Richard; Cormier, Hugues; Cote, Gilles; Cyr, Joanne; David, Pierre; De Benedictis, Luigi; Delisle, Marie-Claude; Deschenes, Patricia; D. Desjardins, Cindy; Desmarais, Gilbert; Dubreucq, Jean-Luc; Dumont, Mimi; Dumais, Alexandre; Ethier, Guylaine; Feltrin, Carole; Felx, Amelie; Findlay, Helen; Fortier, Linda; Fortin, Denise; Fortin, Leo; Francois, Nathe; Gagne, Valerie; Gagnon, Marie-Pierre; Gignac-Hens, Marie-Claude; Giguere, Charles-Edouard; Godbout, Roger; Grou, Christine; Guay, Stephane; Guillem, Francois; Hachimi-Idrissi, Najia; Herry, Christophe; Hodgins, Sheilah; Homayoun, Saffron; Jemel, Boutheina; Joyal, Christian; Kouassi, Edouard; Labelle, Real; Lafortune, Denis; Lahaie, Michel; Lahlafi, Souad; Lalonde, Pierre; Landry, Pierre; Lapaige, Veronique; Larocque, Guylaine; Larue, Caroline; Lavoie, Marc; Leclerc, Jean-Jacques; Lecomte, Tania; Lecours, Cecile; Leduc, Louise; Lelan, Marie-France; Lemieux, Andre; Lesage, Alain; Letarte, Andree; Lepage, Jean; Levesque, Alain; Lipp, Olivier; Luck, David; Lupien, Sonia; Lusignan, Felix-Antoine; Lusignan, Richard; J. Luyet, Andre; Lynhiavu, Alykhanhthi; Melun, Jean-Pierre; Morin, Celine; Nicole, Luc; Noel, Francois; Normandeau, Louise; O’Connor, Kieron; Ouellette, Christine; Parent, Veronique; Parizeau, Marie-Helene; Pelletier, Jean-Francois; Pelletier, Julie; Pelletier, Marc; Plusquellec, Pierrich; Poirier, Diane; Potvin, Stephane; Prevost, Guylaine; Prevost, Marie-Josee; Racicot, Pierre; Racine-Gagne, Marie-France; Renaud, Patrice; Ricard, Nicole; Rivet, Sylvie; Rolland, Michel; Sasseville, Marc; Safadi, Gabriel; Smith, Sandra; Smolla, Nicole; Stip, Emmanuel; Teitelbaum, Jakob; Thibault, Alfred; Thibault, Lucie; Thibault, Stephanye; Thomas, Frederic; Todorov, Christo; Tourjman, Valerie; Tranulis, Constantin; Trudeau, Sonia; Trudel, Gilles; Vacri, Nathalie; Valiquette, Luc; Vanier, Claude; Villeneuve, Kathe; Villeneuve, Marie; Vincent, Philippe; Wolfe, Marcel; Xiong, Lan; Zizzi, Angela; Campbell, Matthew; Turecki, Gustavo; Mechawar, Naguib; Menard, Caroline

doi:10.1038/s41467-021-27604-x

Public

Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue

Published in Nature Communications • Jan 10, 2022

Authors:

Laurence Dion-Albert

Alice Cadoret

Ellen Doney

Abstract

Prevalence, symptoms, and treatment of depression suggest that major depressive disorders (MDD) present sex differences. Social stress-induced neurovascular pathology is associated with depressive symptoms in male mice; however, this association is unclear in females. Here, we report that chronic so...

Subject

Transcriptome

Prefrontal cortex

Depression (economics)

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