Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

Xie, Chenglong; Zhuang, Xu‐Xu; Niu, Zhangming; Ai, Ruixue; Lautrup, Sofie; Zheng, Shuangjia; Jiang, Yinghui; Han, Ruiyu; Sen Gupta, Tanima; Cao, Shuqin; José Lagartos-Donate, Mariá; Cai, Cui-Zan; Xie, Liming; Caponio, Domenica; Wang, Wenwen; Schmauck‐Medina, Tomas; Zhang, Jianying; Wang, Heling; Lou, Guofeng; Xiao, Xianglu; Zheng, Wenhua; Palikaras, Konstantinos; Yang, Guang; A. Caldwell, Kim; A. Caldwell, Guy; Shen, Han‐Ming; Nilsen, Hilde; Lu, Jiahong; Fei Fang, Evandro

doi:10.1038/s41551-021-00819-5

Public

Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

Published in Nature Biomedical Engineering • Jan 6, 2022

Authors:

Chenglong Xie

Xu‐Xu Zhuang

Zhangming Niu

Abstract

A reduced removal of dysfunctional mitochondria is common to aging and age-related neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating such impaired mitophagy would benefit from the identification of mitophagy modulators. Here we report the combined use of unsuper...

Subject

Mitophagy

Pharmacophore

Neuroscience

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!