The RNA methyltransferase METTL8 installs m3C32 in mitochondrial tRNAsThr/Ser(UCN) to optimise tRNA structure and mitochondrial translation

Kleiber, Nicole; Lemus-Diaz, Nicolás; Stiller, Carina; Heinrichs, Marleen; Mong-Quyen Mai, Mandy; Hackert, Philipp; Richter‐Dennerlein, Ricarda; Höbartner, Claudia; E. Bohnsack, Katherine; T. Bohnsack, Markus

doi:10.1038/s41467-021-27905-1

Public

The RNA methyltransferase METTL8 installs m3C32 in mitochondrial tRNAsThr/Ser(UCN) to optimise tRNA structure and mitochondrial translation

Published in Nature Communications • Jan 11, 2022

Authors:

Nicole Kleiber

Nicolás Lemus-Diaz

Carina Stiller

Abstract

Abstract Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial matrix protein and active RNA methyltransferase responsible for installing m3C32 in the human mitochondrial (mt-)tRNAThr and mt-tRNASer(UCN). METTL8 crossl...

Subject

Transfer RNA

Translation (biology)

Biology

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