SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

J. Halfmann, Peter; Iida, Shun; Iwatsuki-Horimoto, Kiyoko; Maemura, Tadashi; Kiso, Maki; M. Scheaffer, Suzanne; L. Darling, Tamarand; Joshi, Astha; Loeber, Samantha; Singh, Gagandeep; L. Foster, Stephanie; Ying, Baoling; Brett Case, James; Chong, Zhenlu; Whitener, Bradley; Moliva, Juan; Floyd, Katharine; Ujie, Michiko; Nakajima, Noriko; Ito, Mutsumi; Wright, Ryan; Uraki, Ryuta; Warang, Prajakta; Gagne, Matthew; Li, Rong; Sakai-Tagawa, Yuko; Liu, Yanan; Larson, Deanna; E. Osorio, Jorge; P. Hernandez-Ortiz, Juan; R. Henry, Amy; Ciuoderis, Karl; R. Florek, Kelsey; Patel, Mit; Odle, Abby; Roy Wong, Lok-Yin; C. Bateman, Allen; Wang, Zhongde; Edara, Venkata-Viswanadh; Chong, Zhenlu; Franks, John; Jeevan, Trushar; Fabrizio, Thomas; DeBeauchamp, Jennifer; Kercher, Lisa; Seiler, Patrick; Silvia Gonzalez-Reiche, Ana; Mia Sordillo, Emilia; A. Chang, Lauren; van Bakel, Harm; Simon, Viviana; Mount Sinai Pathogen Surveillance (PSP) study group, Consortium; Alburquerque, B.; Alshammary, H.; A. Amoako, A.; Aslam, S.; Banu, R.; Cognigni, C.; Espinoza-Moraga, M.; Farrugia, K.; van de Guchte, A.; Khalil, Z.; Laporte, M.; Mena, I.; E. Paniz-Mondolfi, A.; Polanco, J.; Rooker, A.; A. Sominsky, L.; C. Douek, Daniel; J. Sullivan, Nancy; B. Thackray, Larissa; Ueki, Hiroshi; Yamayoshi, Seiya; Imai, Masaki; Perlman, Stanley; J. Webby, Richard; A. Seder, Robert; S. Suthar, Mehul; García-Sastre, Adolfo; Schotsaert, Michael; Suzuki, Tadaki; C. M. Boon, Adrianus; S. Diamond, Michael; Kawaoka, Yoshihiro

doi:10.1038/s41586-022-04441-6

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SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

Shared by NobleBlocks on Jan 21, 2022 • 12:00 AM UTC

Authors:

Peter J. Halfmann

Shun Iida

Kiyoko Iwatsuki-Horimoto

Abstract

Abstract The recent emergence of B.1.1.529, the Omicron variant 1,2 , has raised concerns of escape from protection by vaccines and therapeutic antibodies. A key test for potential countermeasures against B.1.1.529 is their activity in preclinical rodent models of respiratory tract disease. Here, us...

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