Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior.

D W Yaeger, Jazmine; T Krupp, Kevin; M Jacobs, Benjamin; O Onserio, Benard; L Meyerink, Brandon; T Cain, Jacob; J Ronan, Patrick; J Renner, Kenneth; J DiLeone, Ralph; H Summers, Cliff

doi:10.1016/j.biopsych.2021.12.019

Public

Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior.

Shared by NobleBlocks on May 1, 2022 • 12:00 AM UTC

Authors:

Jazmine D W Yaeger

Kevin T Krupp

Benjamin M Jacobs

Abstract

BACKGROUND: Stress produces differential behavioral responses through select molecular modifications to specific neurocircuitry elements. The orexin (Orx) system targets key components of this neurocircuitry in the basolateral amygdala (BLA). METHODS: We assessed the contribution of intra-BLA Orx1 r...

Subject

Anxious behavior

Fear conditioning

Hypocretin

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