Emergence of methicillin resistance predates the clinical use of antibiotics

Larsen, Jesper; Raisen, Claire; Ba, Xiaoliang; J. Sadgrove, Nicholas; F. Padilla-González, Guillermo; S. J. Simmonds, Monique; Loncaric, Igor; Kerschner, Heidrun; Apfalter, Petra; Hartl, Rainer; Deplano, A.; Vandendriessche, Stien; Černá Bolfíková, Barbora; Hulva, Pavel; Cavling Arendrup, Maiken; Krøger Hare, Rasmus; Barnadas, Céline; Stegger, Marc; N. Sieber, Raphael; Skov, Robert; Petersen, Andreas; Angen, Øystein; Lund Rasmussen, Sophie; Espinosa‐Gongora, Carmen; M. Aarestrup, Frank; Lindholm, Laura; Nykäsenoja, Suvi; Laurent, Frédéric; Becker, Karsten; Walther, Birgit; Kehrenberg, Corinna; Cuny, Christiane; Layer, Franziska; Werner, Guido; Witte, Wolfgang; Stamm, Ivonne; Moroni, P.; Joan Jørgensen, Hannah; de Lencastre, Hermı́nia; Cercenado, Emilia; Garcı́a-Garrote, Fernando; Börjesson, Stefan; Hæggman, Sara; Perreten, Vincent; Teale, Christopher; S. Waller, Andrew; Pichon, Bruno; D. Curran, Martin; J. Ellington, Matthew; J. Welch, John; J. Peacock, Sharon; J. Seilly, David; J. E. Morgan, Fiona; Parkhill, Julian; F. Hadjirin, Nazreen; A. Lindsay, Jodi; T. G. Holden, Matthew; Edwards, Giles; Foster, Geoffrey; K. Paterson, Gavin; Didelot, Xavier; A. Holmes, Mark; M. Harrison, Ewan; Rhod Larsen, Anders

doi:10.1038/s41586-021-04265-w

Public

Emergence of methicillin resistance predates the clinical use of antibiotics

Published in Nature • Jan 5, 2022

Authors:

Jesper Larsen

Claire Raisen

Xiaoliang Ba

Abstract

Abstract The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of ...

Subject

Antibiotics

Antibiotic resistance

Resistance (ecology)

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