TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures

A. Chaurio, Ricardo; M. Anadon, Carmen; Lee Costich, Tara; K. Payne, Kyle; Biswas, Subir; M. Harro, Carly; Moran Segura, Carlos; Ortiz, Antonio; Cortina, Carla; E. Rigolizzo, Kristen; B. Sprenger, Kimberly; A. Mine, Jessica; Innamarato, Patrick; Mandal, Gunjan; J. Powers, John; Martin, Alexandra; Wang, Zhitao; Mehta, Sumit; A. Perez, Bradford; Li, Roger; Robinson, John; L. Kroeger, Jodi; J. Curiel, Tyler; Yu, Xiaoqing; C. Rodrı́guez, Paulo; R. Conejo-García, José

doi:10.1016/j.immuni.2021.12.007

Public

TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures

Published in Immunity • Jan 1, 2022

Authors:

Ricardo A. Chaurio

Carmen M. Anadon

Tara Lee Costich

Abstract

The immune checkpoint receptor PD-1 on T follicular helper (Tfh) cells promotes Tfh:B cell interactions and appropriate positioning within tissues. Here, we examined the impact of regulation of PD-1 expression by the genomic organizer SATB1 on Tfh cell differentiation. Vaccination of CD4 Cre Satb1 f...

Subject

Biology

Germinal center

Cancer research

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